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Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men

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  • Andrew D Redd
  • Marie Helleberg
  • Matthew Sievers
  • Stephen D Schmidt
  • Nicole A Doria-Rose
  • Daniel Bruno
  • Shelby Traeger
  • Craig Martens
  • Jannik Fonager
  • Gitte Kronborg
  • Zoe Packman
  • John R Mascola
  • Stephen F Porcella
  • Jan Gerstoft
  • Thomas C Quinn
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BACKGROUND: The role of the anti-HIV neutralizing antibody response in protecting against HIV superinfection, and changes in neutralizing antibody potency and breadth after HIV superinfection have not been fully elucidated. This study examined the rate of HIV superinfection in men who have sex with men (MSM) also diagnosed with syphilis in Denmark, and the anti-HIV neutralizing antibody response in men who became superinfected.

MATERIALS AND METHODS: MSM enrolled in the Danish HIV cohort who acquired syphilis were examined longitudinally for HIV superinfection using a validated next-generation sequencing assay. HIV superinfection cases were matched 3:1 to controls, and neutralizing antibody responses before (cases/controls) and after (cases) HIV superinfection were determined using a 20-pseudovirus panel.

RESULTS: Four cases of HIV superinfection were identified from 95 MSM screened for a rate of HIV superinfection of 1.56/100 pys (95% CI = 0.43-4.01). Prior to HIV superinfection neutralizing antibody responses were low in breadth and potency, and did not differ between cases and controls (p = 1.0). In cases, neutralizing antibody responses increased modestly after HIV superinfection.

CONCLUSIONS: These data support the theory that the natural neutralizing antibody response to HIV infection may not be the controlling factor in protecting against a subsequent HIV challenge.

Original languageEnglish
JournalInfectious Diseases
Volume51
Issue number1
Pages (from-to)56-61
Number of pages6
ISSN2374-4235
DOIs
Publication statusPublished - Jan 2019

ID: 55449774