Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients

Mads Hornum; Klaus Leth Mortensen; Anne-Lise Kamper; Ase Bengård Andersen

doi:10.1016/j.ejim.2007.03.020

Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients

Mads Hornum, Klaus Leth Mortensen, Anne-Lise Kamper, Ase Bengård Andersen

12 Citations (Scopus)

Abstract

Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.

Original language	English
Journal	European Journal of Internal Medicine
Volume	19
Issue number	2
Pages (from-to)	137-9
Number of pages	3
ISSN	0953-6205
DOIs	https://doi.org/10.1016/j.ejim.2007.03.020
Publication status	Published - Mar 2008

Keywords

False Negative Reactions
Female
Humans
Immunocompromised Host
Male
Middle Aged
Mycobacterium tuberculosis
Sensitivity and Specificity
Tuberculosis, Pulmonary

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10.1016/j.ejim.2007.03.020

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title = "Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients",

abstract = "Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.",

keywords = "False Negative Reactions, Female, Humans, Immunocompromised Host, Male, Middle Aged, Mycobacterium tuberculosis, Sensitivity and Specificity, Tuberculosis, Pulmonary",

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T1 - Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients

AU - Hornum, Mads

AU - Mortensen, Klaus Leth

AU - Kamper, Anne-Lise

AU - Andersen, Ase Bengård

PY - 2008/3

Y1 - 2008/3

N2 - Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.

AB - Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.

KW - False Negative Reactions

KW - Female

KW - Humans

KW - Immunocompromised Host

KW - Male

KW - Middle Aged

KW - Mycobacterium tuberculosis

KW - Sensitivity and Specificity

KW - Tuberculosis, Pulmonary

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DO - 10.1016/j.ejim.2007.03.020

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SP - 137

EP - 139

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

IS - 2

ER -

Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients

Abstract

Keywords

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