Abstract
BACKGROUND: We tested if duration and intensity of episodes in treatment-resistant affectively ill patients were related to cerebrospinal fluid (CSF) concentrations of monoamine metabolites.
METHOD: In retrospective life charts were recorded every previous episode of 37 patients with severe treatment-refractory affective disorders. 'Accumulated burden of mood swings' (ABMS, sum of each episode length x episode depth) was used to estimate the accumulated illness burden. Homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5-HIAA) were analyzed in CSF of all patients and compared with 27 healthy controls. Data were analyzed using multiple regression analysis.
RESULTS: CSF MHPG contributed strongly significant and positively to the ABMS.
LIMITATIONS: The retrospective nature of the study.
CONCLUSION: CSF concentrations of MHPG is positively related to ABMS over life. Thus, a specific involvement of norepinephrine in the long-term burden of affective illness is a likely reality.
| Original language | English |
|---|---|
| Journal | Journal of Affective Disorders |
| Volume | 74 |
| Issue number | 2 |
| Pages (from-to) | 185-9 |
| Number of pages | 5 |
| ISSN | 0165-0327 |
| Publication status | Published - Apr 2003 |
| Externally published | Yes |
Keywords
- Antidepressive Agents
- Brain
- Depressive Disorder
- Drug Resistance
- Female
- Homovanillic Acid
- Humans
- Male
- Methoxyhydroxyphenylglycol
- Middle Aged
- Mood Disorders
- Norepinephrine
- Retrospective Studies
- Spinal Puncture
- Journal Article
Fingerprint
Dive into the research topics of 'Lifetime burden of mood swings and activation of brain norepinephrine turnover in patients with treatment-refractory depressive illness'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS