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Levels of tissue inhibitor of metalloproteinases 1 in plasma and urine from patients with cancer

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  1. Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain

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  2. Tissue inhibitor of metalloproteinases-1 as a biological marker 
in colorectal cancer: influence of smoking on plasma levels?

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  3. Aberrantly methylated DNA as a biomarker in breast cancer

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  4. Assessment of the biological variation of plasma tissue inhibitor of metalloproteinases-1

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  1. Triage May Improve Selection to Colonoscopy and Reduce the Number of Unnecessary Colonoscopies

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  2. Helicobacter pylori Colonization Drives Urokinase Receptor (uPAR) Expression in Murine Gastric Epithelium During Early Pathogenesis

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AIM: To assess the potential use of plasma and urine levels of tissue inhibitor of metalloproteinases 1 (TIMP-1) in urothelial cancer. METHODS: TIMP-1 levels were determined in urine and plasma from healthy donors (n=26), patients with bacterial bladder infection (n=24), urothelial bladder adenoma (n=3) or adenocarcinoma (n=7). RESULTS: Free and total TIMP-1 in plasma were weakly but significantly correlated with age; urinary TIMP-1 was not. A strong correlation between free and total TIMP-1 in plasma was observed, with an average ratio of 0.85. No correlation between total TIMP-1 in urine and plasma was found (p=0.55). No significant differences in free or total TIMP-1 in plasma were found between healthy individuals, patients with cystitis or bladder cancer (p=0.4). Urinary TIMP-1 levels were significantly increased in patients with cystitis (p=0.001). No apparent differences in TIMP-1 levels were found in patients with bladder cancer at different stages. CONCLUSION: Our previous observation of a weak but significant correlation between plasma TIMP-1 and age was confirmed. Likewise, an association between free and total TIMP-1 in plasma with a ratio of 0.85 was established. No correlation between plasma and urine TIMP-1 was found. Measurement of TIMP-1 in plasma and/or urine is apparently not useful for the identification of bladder cancer.
Original languageEnglish
JournalInternational Journal of Biological Markers
Volume21
Issue number1
Pages (from-to)6-11
Number of pages6
ISSN0393-6155
Publication statusPublished - 2006

ID: 32519157