Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections

Research output: Contribution to journalJournal articlepeer-review

  1. cyCombine allows for robust integration of single-cell cytometry datasets within and across technologies

    Research output: Contribution to journalJournal articlepeer-review

  2. Serum metabolome associated with severity of acute traumatic brain injury

    Research output: Contribution to journalJournal articlepeer-review

  3. Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics

    Research output: Contribution to journalJournal articlepeer-review

  4. Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

    Research output: Contribution to journalJournal articlepeer-review

  1. A randomized placebo-controlled trial of convalescent plasma for adults hospitalized with COVID-19 pneumonia

    Research output: Contribution to journalJournal articlepeer-review

  2. Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19: A Randomized Controlled Trial

    Research output: Contribution to journalJournal articlepeer-review

  3. Lipoprotein(a) during COVID-19 hospitalization: Thrombosis, inflammation, and mortality

    Research output: Contribution to journalJournal articlepeer-review

  4. SARS-CoV-2 Surface Swabs in Locations With Public Access-Potential for Improved Source Control

    Research output: Contribution to journalJournal articlepeer-review

View graph of relations

SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk of breakthrough infection in a fully vaccinated cohort. SARS-CoV-2 anti-spike IgG levels were measured before first SARS-CoV-2 vaccination and at day 21-28, 90 and 180, as well as after booster vaccination. Breakthrough infections were captured through the Danish National Microbiology database. incidence rate ratio (IRR) for breakthrough infection at time-updated anti-spike IgG levels was determined using Poisson regression. Among 6076 participants, 127 and 364 breakthrough infections due to Delta and Omicron variants were observed. IRR was 0.29 (95% CI 0.15-0.56) for breakthrough infection with the Delta variant, comparing the highest and lowest quintiles of anti-spike IgG. For Omicron, no significant differences in IRR were observed. These results suggest that quantitative level of anti-spike IgG have limited impact on the risk of breakthrough infection with Omicron.

Original languageEnglish
Article number4466
JournalNature Communications
Volume13
Issue number1
Pages (from-to)1-8
Number of pages8
ISSN2041-1722
DOIs
Publication statusPublished - 1 Aug 2022

Bibliographical note

© 2022. The Author(s).

    Research areas

  • Antibodies, Viral, COVID-19, COVID-19 Vaccines, Humans, Immunoglobulin G, SARS-CoV-2

ID: 79862367