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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures

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Brain cancer stem-like cells (bCSC) are cancer cells with neural stem cell (NSC)-like properties found in glioblastoma multiforme (GBM) and they are assigned a central role in tumor initiation, progression and relapse. The Notch pathway is important for maintenance and cell fate decisions in the normal NSC population. Notch signaling is often deregulated in GBM and recent results suggest that this pathway plays a significant role in bCSC as well. We therefore wished to further elucidate the role of Notch activation in GBM-derived bCSC.
Original languageEnglish
JournalCancer Biology & Therapy
Volume14
Issue number7
Pages (from-to)625-37
Number of pages13
ISSN1538-4047
DOIs
Publication statusPublished - Jul 2013

ID: 42485188