Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Lessons learned from histological step-sectioning of sentinel lymph nodes in penile cancer

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Pitfalls of histopathological evaluation of EUS guided microbiopsies from pancreatic cystic neoplasms

    Research output: Contribution to journalLetterResearchpeer-review

  2. Application of automated image analysis reduces the workload of manual screening of sentinel lymph node biopsies in breast cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. TRPM4 expression is associated with activated B cell subtype and poor survival in diffuse large B cell lymphoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Detection of Clinically Significant Prostate Cancer by Systematic TRUS-Biopsies in a Population-Based Setting Over a 20 Year Period

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pheochromocytoma induced cardiomyopathy in a young man: a case report

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. AZGP1 Protein Expression in Hormone-Naive Advanced Prostate Cancer Treated with Primary Androgen Deprivation Therapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Genotype-phenotype associations in PPGLs in 59 patients with variants in SDHX genes

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIMS: Histopathological examination of sentinel lymph nodes in penile cancer has varied during the first 10 years after introduction of the dynamic sentinel node (SLN) procedure in Denmark, and guidelines have been sparse. The aim of this study was to investigate the impact of rigorous step-sectioning of sentinel lymph nodes in penile cancer and improve guidelines.

METHODS AND RESULTS: Seventy-two penile squamous cell carcinoma patients undergoing SLN procedure at a single institution in 2000-2010 were included. The archived lymph node tissues already subjected to a standard pathological examination were retrieved and the initially negative lymph nodes were subjected to an extended step-sectioning procedure. The results were compared to clinical patient outcome from a national database and subsequent pathology reports. The original histopathological examination had detected 26 SLN with metastasis, 21 macro metastases and five micro metastases. The additional step-sectioning procedure of this study generated 4606 slides; seven SLN metastases, two macro metastases and five micro metastases, were detected. One of the macro metastases originated from a patient in which a clinical relapse had occurred in the same groin. None of the other metastases detected in this study showed ipsilateral relapse during follow-up.

CONCLUSION: The results underline the value of our current practice of step-sectioning sentinel lymph nodes in penile cancer and the need for histopathological routines and guidelines. The Danish national guidelines on histopathological handling of sentinel lymph nodes have been adapted to detect any potential clinically relevant metastases.

Original languageEnglish
JournalHistopathology
Volume78
Issue number4
Pages (from-to)627-633
Number of pages7
ISSN0309-0167
DOIs
Publication statusPublished - Mar 2021

Bibliographical note

Publisher Copyright:
© 2020 John Wiley & Sons Ltd

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • lymph node metastases, penile squamous cell carcinoma (PSCC), sentinel node biopsy, step-sectioning

ID: 63733555