Lessons from an international trial evaluating vaccination strategies for recovered inpatients with COVID-19 (VATICO)

Eleftherios Mylonakis; Joseph Lutaakome; Mamta K Jain; Angela J Rogers; José Moltó; Susana Benet; Ahmad Mourad; D Clark Files; Henry Mugerwa; Cissy Kityo; Francis Kiweewa; Mary Grace Nalubega; Jonathan Kitonsa; Evelyn Nabenkema; Daniel D Murray; Dominique Braun; Dena Kamel; Elizabeth S Higgs; Timothy J Hatlen; Virginia L Kan; Adriana Sanchez; John Tierney; Eileen Denner; Deborah Wentworth; Abdel G Babiker; Victoria J Davey; Annetine C Gelijns; Gail V Matthews; B Taylor Thompson; H Clifford Lane; James D Neaton; Jens D Lundgren

doi:10.1016/j.medj.2022.07.003

Lessons from an international trial evaluating vaccination strategies for recovered inpatients with COVID-19 (VATICO)

Eleftherios Mylonakis^*, Joseph Lutaakome, Mamta K Jain, Angela J Rogers, José Moltó, Susana Benet, Ahmad Mourad, D Clark Files, Henry Mugerwa, Cissy Kityo, Francis Kiweewa, Mary Grace Nalubega, Jonathan Kitonsa, Evelyn Nabenkema, Daniel D Murray, Dominique Braun, Dena Kamel, Elizabeth S Higgs, Timothy J Hatlen, Virginia L KanAdriana Sanchez, John Tierney, Eileen Denner, Deborah Wentworth, Abdel G Babiker, Victoria J Davey, Annetine C Gelijns, Gail V Matthews, B Taylor Thompson, H Clifford Lane, James D Neaton, Jens D Lundgren

^*Corresponding author for this work

Department of Infectious Diseases

3 Citations (Scopus)

Abstract

The protection provided by natural versus hybrid immunity from COVID-19 is unclear. We reflect on the challenges from trying to conduct a randomized post-SARS-CoV-2 infection vaccination trial study with rapidly evolving scientific data, vaccination guidelines, varying international policies, difficulties with vaccine availability, vaccine hesitancy, and a constantly evolving virus.

Original language	English
Journal	Med (New York, N.Y.)
Volume	3
Issue number	8
Pages (from-to)	531-537
Number of pages	7
ISSN	2666-6340
DOIs	https://doi.org/10.1016/j.medj.2022.07.003
Publication status	Published - 12 Aug 2022

Keywords

COVID-19/prevention & control
COVID-19 Vaccines
Humans
Inpatients
Randomized Controlled Trials as Topic
Vaccination/methods

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10.1016/j.medj.2022.07.003

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Mylonakis, E., Lutaakome, J., Jain, M. K., Rogers, A. J., Moltó, J., Benet, S., Mourad, A., Files, D. C., Mugerwa, H., Kityo, C., Kiweewa, F., Nalubega, M. G., Kitonsa, J., Nabenkema, E., Murray, D. D., Braun, D., Kamel, D., Higgs, E. S., Hatlen, T. J., ... Lundgren, J. D. (2022). Lessons from an international trial evaluating vaccination strategies for recovered inpatients with COVID-19 (VATICO). Med (New York, N.Y.), 3(8), 531-537. https://doi.org/10.1016/j.medj.2022.07.003

Mylonakis, E, Lutaakome, J, Jain, MK, Rogers, AJ, Moltó, J, Benet, S, Mourad, A, Files, DC, Mugerwa, H, Kityo, C, Kiweewa, F, Nalubega, MG, Kitonsa, J, Nabenkema, E, Murray, DD, Braun, D, Kamel, D, Higgs, ES, Hatlen, TJ, Kan, VL, Sanchez, A, Tierney, J, Denner, E, Wentworth, D, Babiker, AG, Davey, VJ, Gelijns, AC, Matthews, GV, Thompson, BT, Lane, HC, Neaton, JD & Lundgren, JD 2022, 'Lessons from an international trial evaluating vaccination strategies for recovered inpatients with COVID-19 (VATICO)', Med (New York, N.Y.), vol. 3, no. 8, pp. 531-537. https://doi.org/10.1016/j.medj.2022.07.003

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title = "Lessons from an international trial evaluating vaccination strategies for recovered inpatients with COVID-19 (VATICO)",

abstract = "The protection provided by natural versus hybrid immunity from COVID-19 is unclear. We reflect on the challenges from trying to conduct a randomized post-SARS-CoV-2 infection vaccination trial study with rapidly evolving scientific data, vaccination guidelines, varying international policies, difficulties with vaccine availability, vaccine hesitancy, and a constantly evolving virus.",

keywords = "COVID-19/prevention \& control, COVID-19 Vaccines, Humans, Inpatients, Randomized Controlled Trials as Topic, Vaccination/methods",

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doi = "10.1016/j.medj.2022.07.003",

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AU - Jain, Mamta K

AU - Rogers, Angela J

AU - Moltó, José

AU - Benet, Susana

AU - Mourad, Ahmad

AU - Files, D Clark

AU - Mugerwa, Henry

AU - Kityo, Cissy

AU - Kiweewa, Francis

AU - Nalubega, Mary Grace

AU - Kitonsa, Jonathan

AU - Nabenkema, Evelyn

AU - Murray, Daniel D

AU - Braun, Dominique

AU - Kamel, Dena

AU - Higgs, Elizabeth S

AU - Hatlen, Timothy J

AU - Kan, Virginia L

AU - Sanchez, Adriana

AU - Tierney, John

AU - Denner, Eileen

AU - Wentworth, Deborah

AU - Babiker, Abdel G

AU - Davey, Victoria J

AU - Gelijns, Annetine C

AU - Matthews, Gail V

AU - Thompson, B Taylor

AU - Lane, H Clifford

AU - Neaton, James D

AU - Lundgren, Jens D

PY - 2022/8/12

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AB - The protection provided by natural versus hybrid immunity from COVID-19 is unclear. We reflect on the challenges from trying to conduct a randomized post-SARS-CoV-2 infection vaccination trial study with rapidly evolving scientific data, vaccination guidelines, varying international policies, difficulties with vaccine availability, vaccine hesitancy, and a constantly evolving virus.

KW - COVID-19/prevention & control

KW - COVID-19 Vaccines

KW - Humans

KW - Inpatients

KW - Randomized Controlled Trials as Topic

KW - Vaccination/methods

UR - https://www.scopus.com/pages/publications/85135901219

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DO - 10.1016/j.medj.2022.07.003

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C2 - 35963234

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JO - Med (New York, N.Y.)

JF - Med (New York, N.Y.)

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ER -

Lessons from an international trial evaluating vaccination strategies for recovered inpatients with COVID-19 (VATICO)

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Keywords

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