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Leptin in first trimester pregnancy serum: No reduction associated with small-for-gestational-age infants

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@article{3923f8a4c79645ceb7c078be97bbe57d,
title = "Leptin in first trimester pregnancy serum: No reduction associated with small-for-gestational-age infants",
abstract = "Leptin is an adipocytokine that is also synthesized by the placenta. Leptin and its receptor, which is also expressed by the placenta, are believed to play an auto- and paracrine role in trophoblast invasion and placental development. The leptin concentration in first trimester maternal serum and its relation to fetal growth disturbances were examined in this study. The study is a case-control study with 36 small-for-gestational-age (SGA) (<5th percentile) pregnancies and 108 appropriate-for-gestational-age (AGA) (≥5th percentile) pregnancies. The groups were matched by maternal age, gestational age and body mass index (BMI). All were non-smokers. Leptin was measured in maternal serum in weeks 8-13 and was normalized for BMI with concentrations expressed as multiples of the median for the actual BMI. It was found that maternal serum leptin increased strongly (r = 0.7, P < 10-4) with maternal BMI. There was no significant difference in maternal serum leptin concentrations between SGA and AGA pregnancies. In conclusion, SGA pregnancies are not associated with a lower maternal serum leptin concentration in first trimester. The maternal serum leptin concentration is largely determined by maternal BMI. Variation in the leptin concentration in maternal serum in first trimester does not seem to be associated with impaired fetal growth.",
keywords = "First trimester marker, Leptin, Reduced fetal growth, Small-for-age fetus",
author = "Paula Hedley and Kasper Pihl and Lone Krebs and Torben Larsen and Michael Christiansen",
note = "Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2009",
month = jun,
doi = "10.1016/S1472-6483(10)60034-X",
language = "English",
volume = "18",
pages = "832--837",
journal = "Reproductive BioMedicine Online",
issn = "1472-6483",
publisher = "Reproductive Healthcare Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Leptin in first trimester pregnancy serum

T2 - No reduction associated with small-for-gestational-age infants

AU - Hedley, Paula

AU - Pihl, Kasper

AU - Krebs, Lone

AU - Larsen, Torben

AU - Christiansen, Michael

N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2009/6

Y1 - 2009/6

N2 - Leptin is an adipocytokine that is also synthesized by the placenta. Leptin and its receptor, which is also expressed by the placenta, are believed to play an auto- and paracrine role in trophoblast invasion and placental development. The leptin concentration in first trimester maternal serum and its relation to fetal growth disturbances were examined in this study. The study is a case-control study with 36 small-for-gestational-age (SGA) (<5th percentile) pregnancies and 108 appropriate-for-gestational-age (AGA) (≥5th percentile) pregnancies. The groups were matched by maternal age, gestational age and body mass index (BMI). All were non-smokers. Leptin was measured in maternal serum in weeks 8-13 and was normalized for BMI with concentrations expressed as multiples of the median for the actual BMI. It was found that maternal serum leptin increased strongly (r = 0.7, P < 10-4) with maternal BMI. There was no significant difference in maternal serum leptin concentrations between SGA and AGA pregnancies. In conclusion, SGA pregnancies are not associated with a lower maternal serum leptin concentration in first trimester. The maternal serum leptin concentration is largely determined by maternal BMI. Variation in the leptin concentration in maternal serum in first trimester does not seem to be associated with impaired fetal growth.

AB - Leptin is an adipocytokine that is also synthesized by the placenta. Leptin and its receptor, which is also expressed by the placenta, are believed to play an auto- and paracrine role in trophoblast invasion and placental development. The leptin concentration in first trimester maternal serum and its relation to fetal growth disturbances were examined in this study. The study is a case-control study with 36 small-for-gestational-age (SGA) (<5th percentile) pregnancies and 108 appropriate-for-gestational-age (AGA) (≥5th percentile) pregnancies. The groups were matched by maternal age, gestational age and body mass index (BMI). All were non-smokers. Leptin was measured in maternal serum in weeks 8-13 and was normalized for BMI with concentrations expressed as multiples of the median for the actual BMI. It was found that maternal serum leptin increased strongly (r = 0.7, P < 10-4) with maternal BMI. There was no significant difference in maternal serum leptin concentrations between SGA and AGA pregnancies. In conclusion, SGA pregnancies are not associated with a lower maternal serum leptin concentration in first trimester. The maternal serum leptin concentration is largely determined by maternal BMI. Variation in the leptin concentration in maternal serum in first trimester does not seem to be associated with impaired fetal growth.

KW - First trimester marker

KW - Leptin

KW - Reduced fetal growth

KW - Small-for-age fetus

UR - http://www.scopus.com/inward/record.url?scp=68249108069&partnerID=8YFLogxK

U2 - 10.1016/S1472-6483(10)60034-X

DO - 10.1016/S1472-6483(10)60034-X

M3 - Journal article

AN - SCOPUS:68249108069

VL - 18

SP - 832

EP - 837

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 6

M1 - 3654

ER -

ID: 65858847