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Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery

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@article{a7f7e38af2aa413e83862dae0c445985,
title = "Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery",
abstract = "The present study examined whether a marked reduction in oxygen delivery, unlike findings in moderate-intensity exercise, would slow leg oxygen uptake (Vo2) kinetics during intense exercise (86 ± 3{\%} of incremental test peak power). Seven healthy males (26 ± 1 years, means ± SE) performed one-legged knee-extensor exercise (60 ± 3 W) for 4 min in a control setting (CON) and with arterial infusion of N(G)-monomethyl-l-arginine and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50{\%} lower (P",
keywords = "Adult, Blood Gas Analysis, Blood Pressure, Cyclooxygenase Inhibitors, Data Interpretation, Statistical, Enzyme Inhibitors, Exercise, Hemodynamics, Humans, Hydrogen-Ion Concentration, Indomethacin, Lactic Acid, Leg, Male, Muscle Fibers, Fast-Twitch, Muscle, Skeletal, Oxygen Consumption, Potassium, Recruitment, Neurophysiological, Regional Blood Flow, omega-N-Methylarginine",
author = "Christensen, {Peter Quist} and Michael Nyberg and Mortensen, {Stefan P} and Nielsen, {Jens Jung} and Secher, {Niels H} and Rasmus Damsgaard and Ylva Hellsten and Jens Bangsbo",
year = "2013",
month = "8",
day = "1",
doi = "10.1152/ajpregu.00048.2013",
language = "English",
volume = "305",
pages = "R313--21",
journal = "A J P: Regulatory, Integrative and Comparative Physiology (Online)",
issn = "1522-1490",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery

AU - Christensen, Peter Quist

AU - Nyberg, Michael

AU - Mortensen, Stefan P

AU - Nielsen, Jens Jung

AU - Secher, Niels H

AU - Damsgaard, Rasmus

AU - Hellsten, Ylva

AU - Bangsbo, Jens

PY - 2013/8/1

Y1 - 2013/8/1

N2 - The present study examined whether a marked reduction in oxygen delivery, unlike findings in moderate-intensity exercise, would slow leg oxygen uptake (Vo2) kinetics during intense exercise (86 ± 3% of incremental test peak power). Seven healthy males (26 ± 1 years, means ± SE) performed one-legged knee-extensor exercise (60 ± 3 W) for 4 min in a control setting (CON) and with arterial infusion of N(G)-monomethyl-l-arginine and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P

AB - The present study examined whether a marked reduction in oxygen delivery, unlike findings in moderate-intensity exercise, would slow leg oxygen uptake (Vo2) kinetics during intense exercise (86 ± 3% of incremental test peak power). Seven healthy males (26 ± 1 years, means ± SE) performed one-legged knee-extensor exercise (60 ± 3 W) for 4 min in a control setting (CON) and with arterial infusion of N(G)-monomethyl-l-arginine and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P

KW - Adult

KW - Blood Gas Analysis

KW - Blood Pressure

KW - Cyclooxygenase Inhibitors

KW - Data Interpretation, Statistical

KW - Enzyme Inhibitors

KW - Exercise

KW - Hemodynamics

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Indomethacin

KW - Lactic Acid

KW - Leg

KW - Male

KW - Muscle Fibers, Fast-Twitch

KW - Muscle, Skeletal

KW - Oxygen Consumption

KW - Potassium

KW - Recruitment, Neurophysiological

KW - Regional Blood Flow

KW - omega-N-Methylarginine

U2 - 10.1152/ajpregu.00048.2013

DO - 10.1152/ajpregu.00048.2013

M3 - Journal article

VL - 305

SP - R313-21

JO - A J P: Regulatory, Integrative and Comparative Physiology (Online)

JF - A J P: Regulatory, Integrative and Comparative Physiology (Online)

SN - 1522-1490

IS - 3

ER -

ID: 41954214