Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery

Peter Quist Christensen; Michael Nyberg; Stefan P Mortensen; Jens Jung Nielsen; Niels H Secher; Rasmus Damsgaard; Ylva Hellsten; Jens Bangsbo

doi:10.1152/ajpregu.00048.2013

Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery

Peter Quist Christensen, Michael Nyberg, Stefan P Mortensen, Jens Jung Nielsen, Niels H Secher, Rasmus Damsgaard, Ylva Hellsten, Jens Bangsbo

10 Citations (Scopus)

Abstract

The present study examined whether a marked reduction in oxygen delivery, unlike findings in moderate-intensity exercise, would slow leg oxygen uptake (Vo2) kinetics during intense exercise (86 ± 3% of incremental test peak power). Seven healthy males (26 ± 1 years, means ± SE) performed one-legged knee-extensor exercise (60 ± 3 W) for 4 min in a control setting (CON) and with arterial infusion of N(G)-monomethyl-l-arginine and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P

Original language	English
Journal	A J P: Regulatory, Integrative and Comparative Physiology (Online)
Volume	305
Issue number	3
Pages (from-to)	R313-21
ISSN	1522-1490
DOIs	https://doi.org/10.1152/ajpregu.00048.2013
Publication status	Published - 1 Aug 2013

Keywords

Adult
Blood Gas Analysis
Blood Pressure
Cyclooxygenase Inhibitors
Data Interpretation, Statistical
Enzyme Inhibitors
Exercise
Hemodynamics
Humans
Hydrogen-Ion Concentration
Indomethacin
Lactic Acid
Leg
Male
Muscle Fibers, Fast-Twitch
Muscle, Skeletal
Oxygen Consumption
Potassium
Recruitment, Neurophysiological
Regional Blood Flow
omega-N-Methylarginine

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Christensen, P. Q., Nyberg, M., Mortensen, S. P., Nielsen, J. J., Secher, N. H., Damsgaard, R., Hellsten, Y., & Bangsbo, J. (2013). Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery. A J P: Regulatory, Integrative and Comparative Physiology (Online), 305(3), R313-21. https://doi.org/10.1152/ajpregu.00048.2013

Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery. / Christensen, Peter Quist; Nyberg, Michael; Mortensen, Stefan P et al.
In: A J P: Regulatory, Integrative and Comparative Physiology (Online), Vol. 305, No. 3, 01.08.2013, p. R313-21.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "The present study examined whether a marked reduction in oxygen delivery, unlike findings in moderate-intensity exercise, would slow leg oxygen uptake (Vo2) kinetics during intense exercise (86 ± 3% of incremental test peak power). Seven healthy males (26 ± 1 years, means ± SE) performed one-legged knee-extensor exercise (60 ± 3 W) for 4 min in a control setting (CON) and with arterial infusion of N(G)-monomethyl-l-arginine and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P ",

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AU - Secher, Niels H

AU - Damsgaard, Rasmus

AU - Hellsten, Ylva

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AB - The present study examined whether a marked reduction in oxygen delivery, unlike findings in moderate-intensity exercise, would slow leg oxygen uptake (Vo2) kinetics during intense exercise (86 ± 3% of incremental test peak power). Seven healthy males (26 ± 1 years, means ± SE) performed one-legged knee-extensor exercise (60 ± 3 W) for 4 min in a control setting (CON) and with arterial infusion of N(G)-monomethyl-l-arginine and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P

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KW - Blood Gas Analysis

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KW - Data Interpretation, Statistical

KW - Enzyme Inhibitors

KW - Exercise

KW - Hemodynamics

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Indomethacin

KW - Lactic Acid

KW - Leg

KW - Male

KW - Muscle Fibers, Fast-Twitch

KW - Muscle, Skeletal

KW - Oxygen Consumption

KW - Potassium

KW - Recruitment, Neurophysiological

KW - Regional Blood Flow

KW - omega-N-Methylarginine

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DO - 10.1152/ajpregu.00048.2013

M3 - Journal article

C2 - 23720134

SN - 1522-1490

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SP - R313-21

JO - A J P: Regulatory, Integrative and Comparative Physiology (Online)

JF - A J P: Regulatory, Integrative and Comparative Physiology (Online)

IS - 3

ER -

Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery

Abstract

Keywords

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