Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Left Ventricular Systolic Function Assessed by Global Longitudinal Strain is Impaired in Atrial Fibrillation Compared to Sinus Rhythm

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Predictor of Incident Atrial Fibrillation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Systolic and Diastolic Function by Tissue Doppler Imaging Predicts Mortality in Patients with Atrial Fibrillation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Role of PR-Interval In Predicting the Occurrence of Atrial Fibrillation

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The Relationship between physical activity and risk of atrial fibrillation-A systematic review and meta-Analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prognosis and Reclassification by YKL-40 in Stable Coronary Artery Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Sedentary work and risk of venous thromboembolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Resting heart rate and mortality in the very old

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: Atrial fibrillation (AF) is the most common aberrant cardiac arrhythmia. Many AF patients present with symptoms of dyspnea and fatigue, but have normal left ventricular ejection fraction (LVEF).

Purpose: To determine the reproducibility of measurements of global longitudinal strain (GLS) and strain rate in patients with AF and examine if the arrhythmia is associated with abnormal LV strain and strain rate independent of age, sex, heart rate, LVEF and LV mass. We hypothesized that AF independently reduces ventricular systolic performance.

Methods: The study was conducted as a retrospective analysis of images from 150 randomly selected patients with AF compared to an equal number of subjects with sinus rhythm (SR) matched for age, sex, heart rate, LVEF and LV mass. Half of the patients had normal LVEF (LVEF > 50%) and half had reduced LVEF (LVEF < 50%). GLS and strain rate were measured in each group, as were quantitative LV volumes and standard systolic and diastolic parameters. Results: GLS was significantly impaired in patients with AF compared to subjects with SR, both in the overall population (-12.25 ± 4.1% vs. -16.13 ± 4.7%, p<0.0001), in patients with normal LVEF (-14.41 ± 3.9% vs. -19.42 ± 3.1%, p<0.0001) and in patients with reduced LVEF (-10.10 ± 3.1% vs. -12.85 ± 3.5%, p<0.0001).Linear regression and Bland Altman analyses demonstrated good intraobserver and interobserver agreement for measurements of GLS and strain rate parameters even in patients with AF.

Original languageEnglish
JournalJournal of Atrial Fibrillation
Volume10
Issue number4
ISSN1941-6911
DOIs
Publication statusPublished - 1 Mar 2018

    Research areas

  • Journal Article

ID: 53366730