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Left ventricular remodelling and cardiac chamber sizes in long-term, normoalbuminuric type 1 diabetes patients with and without cardiovascular autonomic neuropathy

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@article{220136fdbb294422ae35a9c208073dbe,
title = "Left ventricular remodelling and cardiac chamber sizes in long-term, normoalbuminuric type 1 diabetes patients with and without cardiovascular autonomic neuropathy",
abstract = "AIMS: Type 1 diabetes is associated with increased cardiovascular (CV) morbidity and mortality, and cardiovascular autonomic neuropathy (CAN) is an important CV risk factor. The study aimed to explore associations between CAN and altered cardiac chamber sizes in persons with type 1 diabetes.METHODS: This was a cross-sectional study of 71 asymptomatic, normoalbuminuric participants with long-term type 1 diabetes (39 with CAN, determined by >1 abnormal autonomic function test) examined with cardiac multi detector computed tomography scans, which allowed measurements of left ventricular mass and all four cardiac chamber volumes. Cardiac chambers were indexed according to body surface area (ml/m2 or g/m2).RESULTS: Persons with and without CAN had mean ± SD age of 57 ± 7 and 50 ± 8 years (p < 0.001) and diabetes duration of 36 ± 11 and 32 ± 9 years (p < 0.05), respectively. Increasing autonomic dysfunction, evaluated by decrease in heart rate variability during deep breathing (in beats per minute), was associated with larger right (-0.5, 95{\%} CI -1.0 to -0.0, p < 0.05) and trend towards larger left (-0.4, 95{\%} CI -0.8-0.0, p < 0.1) ventricular volumes in multivariable linear regression.CONCLUSIONS: Our results suggest that impaired autonomic function may be associated with modest enlargement of ventricular volumes; this might be an early sign of progression towards heart failure.",
keywords = "Cardiac chamber sizes, Cardiovascular autonomic neuropathy, Cardiovascular disease, Computed tomography, Left ventricular mass, Type 1 diabetes mellitus",
author = "Hjortkj{\ae}r, {Henrik {\O}} and Tonny Jensen and Jannik Hilsted and Mogensen, {Ulrik M} and Helle Corinth and Peter Rossing and Lars K{\o}ber and Kofoed, {Klaus F}",
note = "Copyright {\circledC} 2018 Elsevier Inc. All rights reserved.",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.jdiacomp.2018.10.007",
language = "English",
volume = "33",
pages = "171--177",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc",
number = "2",

}

RIS

TY - JOUR

T1 - Left ventricular remodelling and cardiac chamber sizes in long-term, normoalbuminuric type 1 diabetes patients with and without cardiovascular autonomic neuropathy

AU - Hjortkjær, Henrik Ø

AU - Jensen, Tonny

AU - Hilsted, Jannik

AU - Mogensen, Ulrik M

AU - Corinth, Helle

AU - Rossing, Peter

AU - Køber, Lars

AU - Kofoed, Klaus F

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - AIMS: Type 1 diabetes is associated with increased cardiovascular (CV) morbidity and mortality, and cardiovascular autonomic neuropathy (CAN) is an important CV risk factor. The study aimed to explore associations between CAN and altered cardiac chamber sizes in persons with type 1 diabetes.METHODS: This was a cross-sectional study of 71 asymptomatic, normoalbuminuric participants with long-term type 1 diabetes (39 with CAN, determined by >1 abnormal autonomic function test) examined with cardiac multi detector computed tomography scans, which allowed measurements of left ventricular mass and all four cardiac chamber volumes. Cardiac chambers were indexed according to body surface area (ml/m2 or g/m2).RESULTS: Persons with and without CAN had mean ± SD age of 57 ± 7 and 50 ± 8 years (p < 0.001) and diabetes duration of 36 ± 11 and 32 ± 9 years (p < 0.05), respectively. Increasing autonomic dysfunction, evaluated by decrease in heart rate variability during deep breathing (in beats per minute), was associated with larger right (-0.5, 95% CI -1.0 to -0.0, p < 0.05) and trend towards larger left (-0.4, 95% CI -0.8-0.0, p < 0.1) ventricular volumes in multivariable linear regression.CONCLUSIONS: Our results suggest that impaired autonomic function may be associated with modest enlargement of ventricular volumes; this might be an early sign of progression towards heart failure.

AB - AIMS: Type 1 diabetes is associated with increased cardiovascular (CV) morbidity and mortality, and cardiovascular autonomic neuropathy (CAN) is an important CV risk factor. The study aimed to explore associations between CAN and altered cardiac chamber sizes in persons with type 1 diabetes.METHODS: This was a cross-sectional study of 71 asymptomatic, normoalbuminuric participants with long-term type 1 diabetes (39 with CAN, determined by >1 abnormal autonomic function test) examined with cardiac multi detector computed tomography scans, which allowed measurements of left ventricular mass and all four cardiac chamber volumes. Cardiac chambers were indexed according to body surface area (ml/m2 or g/m2).RESULTS: Persons with and without CAN had mean ± SD age of 57 ± 7 and 50 ± 8 years (p < 0.001) and diabetes duration of 36 ± 11 and 32 ± 9 years (p < 0.05), respectively. Increasing autonomic dysfunction, evaluated by decrease in heart rate variability during deep breathing (in beats per minute), was associated with larger right (-0.5, 95% CI -1.0 to -0.0, p < 0.05) and trend towards larger left (-0.4, 95% CI -0.8-0.0, p < 0.1) ventricular volumes in multivariable linear regression.CONCLUSIONS: Our results suggest that impaired autonomic function may be associated with modest enlargement of ventricular volumes; this might be an early sign of progression towards heart failure.

KW - Cardiac chamber sizes

KW - Cardiovascular autonomic neuropathy

KW - Cardiovascular disease

KW - Computed tomography

KW - Left ventricular mass

KW - Type 1 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=85055104952&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2018.10.007

DO - 10.1016/j.jdiacomp.2018.10.007

M3 - Journal article

VL - 33

SP - 171

EP - 177

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 2

ER -

ID: 55723791