Late Malignant Transformation of a Vestibular Schwannoma without Association to NFII or Radiotherapy

Asma Bashir, Lars Poulsgaard, Helle Broholm, Kåre Fugleholm

Abstract

Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.
Original languageEnglish
Publication date2016
DOIs
Publication statusPublished - 2016
EventDansk Patologiselskab: Anvendt molekylærpatologi - Scandic Hotel, København
Duration: 10 Mar 201612 Mar 2016

Conference

ConferenceDansk Patologiselskab
LocationScandic Hotel, København
Period10/03/201612/03/2016

Fingerprint

Dive into the research topics of 'Late Malignant Transformation of a Vestibular Schwannoma without Association to NFII or Radiotherapy'. Together they form a unique fingerprint.

Cite this