Large-scale studies of the Leu72Met polymorphism of the ghrelin gene in relation to the metabolic syndrome and associated quantitative traits

C Bing, L Ambye, M Fenger, T Jørgensen, K Borch-Johnsen, S Madsbad, S A Urhammer

51 Citations (Scopus)

Abstract

Recently, low-frequency polymorphisms in the coding region of the ghrelin gene were suggested to be involved in the aetiology of obesity and to modulate glucose-induced insulin secretion in different ethnic study groups. The objective of the present large study was to investigate whether the Leu72Met polymorphism of the ghrelin gene associates with features of the metabolic syndrome (MS) in the Danish population.
Original languageEnglish
JournalDiabetic Medicine
Volume22
Issue number9
Pages (from-to)1157-60
Number of pages3
ISSN0742-3071
DOIs
Publication statusPublished - 2005

Keywords

  • Adult
  • Aged
  • Alleles
  • Cohort Studies
  • Denmark
  • Female
  • Gene Frequency
  • Genotype
  • Ghrelin
  • Humans
  • Leucine
  • Male
  • Metabolic Syndrome X
  • Methionine
  • Middle Aged
  • Peptide Hormones
  • Polymorphism, Restriction Fragment Length

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