Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock

Ole K Møller-Helgestad; Hanne B Ravn; Jacob E Møller

doi:10.1007/978-1-4939-8597-5_27

Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock

Ole K Møller-Helgestad
, Hanne B Ravn
, Jacob E Møller

22 Citations (Scopus)

Abstract

Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.

Original language	English
Journal	Methods in molecular biology
Volume	1816
Pages (from-to)	343-352
Number of pages	10
ISSN	1064-3745
DOIs	https://doi.org/10.1007/978-1-4939-8597-5_27
Publication status	Published - 2018

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title = "Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock",

abstract = "Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10\% of patients with large myocardial infarcts with a subsequent mortality rate of 50\%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100\% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.",

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AU - Møller-Helgestad, Ole K

AU - Ravn, Hanne B

AU - Møller, Jacob E

PY - 2018

Y1 - 2018

N2 - Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.

AB - Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.

U2 - 10.1007/978-1-4939-8597-5_27

DO - 10.1007/978-1-4939-8597-5_27

M3 - Journal article

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SN - 1064-3745

VL - 1816

SP - 343

EP - 352

JO - Methods in molecular biology

JF - Methods in molecular biology

ER -

Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock

Abstract

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