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Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.
Original language | English |
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Journal | Methods in molecular biology (Clifton, N.J.) |
Volume | 1816 |
Pages (from-to) | 343-352 |
Number of pages | 10 |
ISSN | 1064-3745 |
DOIs | |
Publication status | Published - 2018 |
ID: 56718617