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Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes: A Scandinavian Case-Cohort Study

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Thorsen, SU, Mårild, K, Olsen, SF, Holst, KK, Tapia, G, Granström, C, Halldorsson, TI, Cohen, AS, Haugen, M, Lundqvist, M, Skrivarhaug, T, Njølstad, PR, Joner, G, Magnus, P, Størdal, K, Svensson, J & Stene, LC 2018, 'Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes: A Scandinavian Case-Cohort Study' American Journal of Epidemiology, vol. 187, no. 6, pp. 1174-1181. https://doi.org/10.1093/aje/kwx361

APA

CBE

Thorsen SU, Mårild K, Olsen SF, Holst KK, Tapia G, Granström C, Halldorsson TI, Cohen AS, Haugen M, Lundqvist M, Skrivarhaug T, Njølstad PR, Joner G, Magnus P, Størdal K, Svensson J, Stene LC. 2018. Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes: A Scandinavian Case-Cohort Study. American Journal of Epidemiology. 187(6):1174-1181. https://doi.org/10.1093/aje/kwx361

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Author

Thorsen, Steffen U ; Mårild, Karl ; Olsen, Sjurdur F ; Holst, Klaus K ; Tapia, German ; Granström, Charlotta ; Halldorsson, Thorhallur I ; Cohen, Arieh S ; Haugen, Margaretha ; Lundqvist, Marika ; Skrivarhaug, Torild ; Njølstad, Pål R ; Joner, Geir ; Magnus, Per ; Størdal, Ketil ; Svensson, Jannet ; Stene, Lars C. / Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes : A Scandinavian Case-Cohort Study. In: American Journal of Epidemiology. 2018 ; Vol. 187, No. 6. pp. 1174-1181.

Bibtex

@article{0699d276cf1744169bf6f38ac8896908,
title = "Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes: A Scandinavian Case-Cohort Study",
abstract = "Studies on vitamin D status during pregnancy and risk of type 1 diabetes (T1D) lack consistency, and are limited by small sample sizes or single measures of 25-hydroxyvitamin D (25(OH)D). We investigated whether average maternal 25(OH)D plasma concentrations during pregnancy are associated with risk of childhood T1D. In a case-cohort design, we identified 459 children with T1D and a random sample (n = 1,561) from the Danish National Birth Cohort (n = 97,127) and Norwegian Mother and Child Cohort Study (n = 113,053). Participants were born between 1996 and 2009. The primary exposure was the estimated average 25(OH)D concentration based on serial samples from the first trimester until delivery, and umbilical cord plasma. We estimated hazard ratios using weighted Cox regression adjusting for multiple confounders. The adjusted hazard ratio for T1D per 10 nmol/L increase in the estimated average 25(OH)D concentration was 1.00 (95{\%} confidence interval: 0.90, 1.10). Results were consistent in both cohorts, in multiple sensitivity analyses, and when we analyzed mid-pregnancy or cord blood separately. In conclusion, our large study demonstrated that normal variation in maternal or neonatal 25(OH)D is unlikely to have a clinically important effect on risk of childhood T1D.",
keywords = "Journal Article",
author = "Thorsen, {Steffen U} and Karl M{\aa}rild and Olsen, {Sjurdur F} and Holst, {Klaus K} and German Tapia and Charlotta Granstr{\"o}m and Halldorsson, {Thorhallur I} and Cohen, {Arieh S} and Margaretha Haugen and Marika Lundqvist and Torild Skrivarhaug and Nj{\o}lstad, {P{\aa}l R} and Geir Joner and Per Magnus and Ketil St{\o}rdal and Jannet Svensson and Stene, {Lars C}",
note = "{\circledC} The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2018",
month = "6",
doi = "10.1093/aje/kwx361",
language = "English",
volume = "187",
pages = "1174--1181",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes

T2 - A Scandinavian Case-Cohort Study

AU - Thorsen, Steffen U

AU - Mårild, Karl

AU - Olsen, Sjurdur F

AU - Holst, Klaus K

AU - Tapia, German

AU - Granström, Charlotta

AU - Halldorsson, Thorhallur I

AU - Cohen, Arieh S

AU - Haugen, Margaretha

AU - Lundqvist, Marika

AU - Skrivarhaug, Torild

AU - Njølstad, Pål R

AU - Joner, Geir

AU - Magnus, Per

AU - Størdal, Ketil

AU - Svensson, Jannet

AU - Stene, Lars C

N1 - © The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2018/6

Y1 - 2018/6

N2 - Studies on vitamin D status during pregnancy and risk of type 1 diabetes (T1D) lack consistency, and are limited by small sample sizes or single measures of 25-hydroxyvitamin D (25(OH)D). We investigated whether average maternal 25(OH)D plasma concentrations during pregnancy are associated with risk of childhood T1D. In a case-cohort design, we identified 459 children with T1D and a random sample (n = 1,561) from the Danish National Birth Cohort (n = 97,127) and Norwegian Mother and Child Cohort Study (n = 113,053). Participants were born between 1996 and 2009. The primary exposure was the estimated average 25(OH)D concentration based on serial samples from the first trimester until delivery, and umbilical cord plasma. We estimated hazard ratios using weighted Cox regression adjusting for multiple confounders. The adjusted hazard ratio for T1D per 10 nmol/L increase in the estimated average 25(OH)D concentration was 1.00 (95% confidence interval: 0.90, 1.10). Results were consistent in both cohorts, in multiple sensitivity analyses, and when we analyzed mid-pregnancy or cord blood separately. In conclusion, our large study demonstrated that normal variation in maternal or neonatal 25(OH)D is unlikely to have a clinically important effect on risk of childhood T1D.

AB - Studies on vitamin D status during pregnancy and risk of type 1 diabetes (T1D) lack consistency, and are limited by small sample sizes or single measures of 25-hydroxyvitamin D (25(OH)D). We investigated whether average maternal 25(OH)D plasma concentrations during pregnancy are associated with risk of childhood T1D. In a case-cohort design, we identified 459 children with T1D and a random sample (n = 1,561) from the Danish National Birth Cohort (n = 97,127) and Norwegian Mother and Child Cohort Study (n = 113,053). Participants were born between 1996 and 2009. The primary exposure was the estimated average 25(OH)D concentration based on serial samples from the first trimester until delivery, and umbilical cord plasma. We estimated hazard ratios using weighted Cox regression adjusting for multiple confounders. The adjusted hazard ratio for T1D per 10 nmol/L increase in the estimated average 25(OH)D concentration was 1.00 (95% confidence interval: 0.90, 1.10). Results were consistent in both cohorts, in multiple sensitivity analyses, and when we analyzed mid-pregnancy or cord blood separately. In conclusion, our large study demonstrated that normal variation in maternal or neonatal 25(OH)D is unlikely to have a clinically important effect on risk of childhood T1D.

KW - Journal Article

U2 - 10.1093/aje/kwx361

DO - 10.1093/aje/kwx361

M3 - Journal article

VL - 187

SP - 1174

EP - 1181

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 6

ER -

ID: 52747888