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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose

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Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.

Translated title of the contributionCombination therapy of thyroxine and triiodothyronine in hypothyroid patients
Original languageDanish
Article numberV04170328
JournalUgeskrift for Laeger
Volume180
Issue number22
Pages (from-to)2-5
ISSN0041-5782
Publication statusPublished - 7 May 2018

ID: 56735002