Knoglemarvstransplantation og chimeric antigen receptor-T-celleterapi

Translated title of the contribution: Bone marrow transplantation and chimeric antigen receptot T cellular therapy

Abstract

Malignant hematologic diseases resistant to chemotherapy can be cured by immune cellular therapy. Bone marrow transplantation (BMT) elicits a "pan-immunologic" attack, whereas therapy with chimeric antigen receptor (CAR)-T is a targeted attack. The immunologic activity after BMT can be adjusted by selection of donor cells before transplantation, or with post-BMT sequential chemotherapy. Many haematologic diseases are clonal, and the development of CAR-T cellular therapy directed against a variety of epitopes is under development as summarised in this review.

Translated title of the contributionBone marrow transplantation and chimeric antigen receptot T cellular therapy
Original languageDanish
Article numberV03210280
JournalUgeskrift for læger [online]
Volume183
Issue number42
Pages (from-to)1-8
Number of pages8
ISSN1603-6824
Publication statusPublished - 18 Oct 2021

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