Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Kisspeptins: bridging energy homeostasis and reproduction

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hippocampal volume and cell number in depression, schizophrenia, and suicide subjects

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Transcriptomic profiling of trigeminal nucleus caudalis and spinal cord dorsal horn

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. DNMT1 regulates expression of MHC class i in post-mitotic neurons

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Body energy reserves and metabolic state are relevant modifiers of puberty onset and fertility; forms of metabolic stress ranging from persistent energy insufficiency to morbid obesity are frequently linked to reproductive disorders. The mechanisms for such a close connection between energy balance and reproduction have been the subject of considerable attention; however, our understanding of the neurobiological basis for this phenomenon is still incomplete. In mid 1990s, the adipose-hormone, leptin, was proven as an essential signal for transmitting metabolic information onto the centers governing puberty and reproduction; yet, the ultimate mode of action of leptin on GnRH neurons has remained contentious for years. More recently, kisspeptins, a family of neuropeptides encoded by the Kiss1 gene, have emerged as conduits for the metabolic regulation of reproduction and putative effectors of leptin actions on GnRH neurons. This review recapitulates the experimental evidence obtained to date, mostly in laboratory rodents, supporting the function of kisspeptins in bridging energy balance and reproduction, with special emphasis on recent developments in this field, such as the recognition of mTOR (mammalian target of rapamycin) and Crtc1 (Creb1-regulated transcription coactivator-1) as putative mediators for leptin regulation of Kiss1 expression, as well as the identification of other potential metabolic modulators of kisspeptin signaling, such as ghrelin, neuropeptide Y (NPY) and melanin-concentrating hormone (MCH).
Original languageEnglish
JournalBrain Research
Volume1364
Pages (from-to)129-38
Number of pages10
DOIs
Publication statusPublished - 10 Dec 2010

ID: 32198164