Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Kinetics of insulin disappearance from plasma in cortisone-treated normal subjects

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Ellemann, K ; Thorsteinsson, B ; Fugleberg, S ; Feldt-Rasmussen, B ; Grønbaek, P ; Binder, C. / Kinetics of insulin disappearance from plasma in cortisone-treated normal subjects. In: Clinical Endocrinology. 1987 ; Vol. 26, No. 5. pp. 623-8.

Bibtex

@article{b2d71b1785b040989bcba938f14d8ecf,
title = "Kinetics of insulin disappearance from plasma in cortisone-treated normal subjects",
abstract = "The effect of glucocorticoid excess on insulin disappearance from plasma was examined in eight normal men during cortisone treatment (50 mg orally twice daily for 4 d) and in the absence of any medication (control) in random order. Constant infusion of insulin (1-5 mU/kg/min) was used to achieve different levels of steady state plasma insulin concentrations; normoglycaemia was preserved by a glucose clamp technique. The experimentally determined data were compared using a previously validated model of saturation kinetics. The amount of glucose required to maintain normoglycaemia during the insulin infusions was significantly less in the cortisone study than in the control study, while the parameter estimates for the kinetics of insulin disappearance from plasma were unaffected by cortisone. Thus, insulin action and insulin kinetics in the steady state are dissociated in normal subjects rendered insulin resistant by short-term cortisone treatment.",
keywords = "Adult, Blood Glucose, C-Peptide, Cortisone, Glucose, Humans, Insulin, Male, Middle Aged",
author = "K Ellemann and B Thorsteinsson and S Fugleberg and B Feldt-Rasmussen and P Gr{\o}nbaek and C Binder",
year = "1987",
month = may,
language = "English",
volume = "26",
pages = "623--8",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Kinetics of insulin disappearance from plasma in cortisone-treated normal subjects

AU - Ellemann, K

AU - Thorsteinsson, B

AU - Fugleberg, S

AU - Feldt-Rasmussen, B

AU - Grønbaek, P

AU - Binder, C

PY - 1987/5

Y1 - 1987/5

N2 - The effect of glucocorticoid excess on insulin disappearance from plasma was examined in eight normal men during cortisone treatment (50 mg orally twice daily for 4 d) and in the absence of any medication (control) in random order. Constant infusion of insulin (1-5 mU/kg/min) was used to achieve different levels of steady state plasma insulin concentrations; normoglycaemia was preserved by a glucose clamp technique. The experimentally determined data were compared using a previously validated model of saturation kinetics. The amount of glucose required to maintain normoglycaemia during the insulin infusions was significantly less in the cortisone study than in the control study, while the parameter estimates for the kinetics of insulin disappearance from plasma were unaffected by cortisone. Thus, insulin action and insulin kinetics in the steady state are dissociated in normal subjects rendered insulin resistant by short-term cortisone treatment.

AB - The effect of glucocorticoid excess on insulin disappearance from plasma was examined in eight normal men during cortisone treatment (50 mg orally twice daily for 4 d) and in the absence of any medication (control) in random order. Constant infusion of insulin (1-5 mU/kg/min) was used to achieve different levels of steady state plasma insulin concentrations; normoglycaemia was preserved by a glucose clamp technique. The experimentally determined data were compared using a previously validated model of saturation kinetics. The amount of glucose required to maintain normoglycaemia during the insulin infusions was significantly less in the cortisone study than in the control study, while the parameter estimates for the kinetics of insulin disappearance from plasma were unaffected by cortisone. Thus, insulin action and insulin kinetics in the steady state are dissociated in normal subjects rendered insulin resistant by short-term cortisone treatment.

KW - Adult

KW - Blood Glucose

KW - C-Peptide

KW - Cortisone

KW - Glucose

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

M3 - Journal article

C2 - 3311480

VL - 26

SP - 623

EP - 628

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 5

ER -

ID: 44941284