Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Kinetic models for plasma disappearance of insulin in normal subjects

Research output: Contribution to journalJournal articleResearchpeer-review

  1. EXPERIMENTAL ARGYROSIS

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. MERCURY ACCUMULATION IN THE ANTERIOR PITUITARY AFTER EXPOSURE TO MERCURIC CHLORIDE

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Selenium accumulation in the oocyte after exposure to sodium selenite

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Vasoactive intestinal polypeptide (VIP) and peripheral vasodilation

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Quantitative liver functions after administration of allyl alcohol to rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Gustatory sweating in people with type 1 and type 2 diabetes mellitus: Prevalence and risk factors

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Does nocturnal hypoglycaemia really improve quality of life? Reply to Søholm U, Broadley MM, Choudhary P et al [letter]

    Research output: Contribution to journalLetterResearchpeer-review

  3. Increased vulnerability to Covid-19 in chronic kidney disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Three theoretical kinetic models for plasma disappearance of insulin were examined in six normal men. The models allowed for the existence of non-saturable and/or saturable mechanisms. Constant infusion of porcine insulin at different rates was used to achieve different levels of steady state plasma insulin concentrations, while normoglycaemia was secured by a glucose clamp technique. Appropriate validation procedures demonstrated that one of the three models was superior to the others in describing the relationship between the exogenous insulin infusion rate Iex and the steady state plasma insulin concentration C: Iex = -Iend + k2 X C/(k3 + C), where Iend is the endogenous post-hepatic insulin delivery rate. Thus, only saturable mechanism(s) could be demonstrated. The median value of k2 (the maximal insulin disappearance rate) and k3 (the plasma insulin concentration at which the insulin disappearance rate is half maximal) were 7.31 nmol X min.-1 and 3.89 nmol X 1-1. The median value of k2/k3 (the clearance rate of insulin for infinitesimal plasma insulin concentrations) was 25.0 ml X kg-1 X min.-1. Thus, at physiological levels of plasma insulin concentrations the metabolic clearance rate of insulin is higher than insulin clearance estimates previously reported in studies based on the assumption of first order kinetics.

Original languageEnglish
JournalActa Pharmacologica et Toxicologica
Volume57
Issue number5
Pages (from-to)309-16
Number of pages8
ISSN0001-6683
Publication statusPublished - Nov 1985

    Research areas

  • Adolescent, Adult, Blood Glucose, C-Peptide, Humans, Insulin, Kinetics, Male, Models, Biological

ID: 44941504