Kinase Signaling in Colitis-Associated Colon Cancer and Inflammatory Bowel Disease

Michelle Temby, Theresa L Boye, Jacqueline Hoang, Ole H Nielsen, John Gubatan

3 Citations (Scopus)

Abstract

Colorectal cancer is a known complication of chronic inflammation of the colon ("colitis-associated colon cancer"). Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Patients with IBD are at increased risk of colon cancer compared to the general population. Kinase signaling pathways play critical roles in both the inflammation and regulating cellular processes such as proliferation and survival that contribute to cancer development. Here we review the interplay of kinase signaling pathways (mitogen-activated protein kinases, cyclin-dependent kinases, autophagy-activated kinases, JAK-STAT, and other kinases) and their effects on colitis-associated colon cancer. We also discuss the role of JAK-STAT signaling in the pathogenesis of IBD and the therapeutic landscape of JAK inhibitors for the treatment of IBD.

Original languageEnglish
Article number1620
JournalBiomolecules
Volume13
Issue number11
ISSN2218-273X
DOIs
Publication statusPublished - 6 Nov 2023

Keywords

  • Humans
  • Colitis-Associated Neoplasms
  • Inflammatory Bowel Diseases/metabolism
  • Janus Kinases/metabolism
  • Inflammation

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