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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Kidney transplant outcomes from older deceased donors: a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry

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  1. Age-related renal function decline in Fabry disease patients on enzyme replacement therapy: a longitudinal cohort study

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  3. Allograft and patient survival after sequential HSCT and kidney transplantation from the same donor-A multicenter analysis

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  • Maria Pippias
  • Kitty J Jager
  • Fergus Caskey
  • Anna Casula
  • Helen Erlandsson
  • Patrik Finne
  • James Heaf
  • Georg Heinze
  • Andries Hoitsma
  • Reinhard Kramar
  • Marko Lempinen
  • Angela Magaz
  • Karsten Midtvedt
  • Lisa L Mumford
  • Julio Pascual
  • Karl G Prütz
  • Søren S Sørensen
  • Jamie P Traynor
  • Ziad A Massy
  • Rommel Ravanan
  • Vianda S Stel
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As the median age of deceased kidney donors rises, updated knowledge of transplant outcomes from older deceased donors in differing donor-recipient age groups is required. Using ERA-EDTA Registry data we determined survival outcomes of kidney allografts donated from the same older deceased donor (55-70 years), and transplanted into one recipient younger and one recipient of similar age to the donor. The recipient pairs were divided into two groups: group 1; younger (median age: 52 years) and older (60 years) and group 2; younger (41 years) and older (60 years). A total of 1410 adults were transplanted during 2000-2007. Compared to the older recipients, the mean number of functioning graft years at 10 years was 6 months longer in the group 1 and group 2 younger recipients (P < 0.001). Ten-year graft survival was 54% and 40% for the group 1 younger and older recipients, and 60% and 49% for the group 2 younger and older recipients. Paired Cox regression analyses showed a lower risk of graft failure (group 1 younger; adjusted relative risk [RRa]:0.57, 95% CI:0.41-0.79, and group 2 younger; RRa:0.63, 95% CI:0.47-0.85) in younger recipients. Outcomes from older deceased donor allografts transplanted into differing donor-recipient age groups are better than previously reported. These allografts remain a valuable transplant resource, particularly for similar-aged recipients.

Original languageEnglish
JournalTransplant international : official journal of the European Society for Organ Transplantation
Volume31
Pages (from-to)708-719
ISSN0934-0874
DOIs
Publication statusPublished - 2017

    Research areas

  • Journal Article

ID: 52633053