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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Kidney function in normal man during short-term growth hormone infusion

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Kidney function was studied in 9 normal males before and during a 2 h growth hormone (GH) infusion of 50 ng/kg/min. The following variables were measured during each 20 min clearance period: glomerular filtration rate, GFR, effective renal plasma flow, RPF (steady state infusion technique with urinary collections using [125I]iothalamate and [131I]iodohippurate), and urinary albumin and beta2-microglobulin excretion rates (radioimmunoassays). The GH infusion resulted in a 10-fold increase in plasma GH concentration. All the above mentioned variables remained practically unchanged during the infusion except for a small (-5%) but significant decrease in renal plasma flow (P less than 0.01). Our negative results contrast to the findings of increased GFR and RPF during prolonged GH administration and suggest that GH requires several hours or days for its renal effects to become manifest.

Original languageEnglish
JournalActa Endocrinologica (Copenh)
Volume89
Issue number4
Pages (from-to)796-800
Number of pages5
ISSN0001-5598
Publication statusPublished - Dec 1978

    Research areas

  • Adult, Albuminuria, Blood Glucose, Glomerular Filtration Rate, Growth Hormone, Humans, Infusions, Parenteral, Kidney, Male, Regional Blood Flow, beta 2-Microglobulin

ID: 44243280