Ketamin til akut depressionsbehandling

Simon Hjerrild; Johannes Bjerre; Rasmus Hjuler Pedersen; Poul Videbech

Ketamin til akut depressionsbehandling

Translated title of the contribution: Ketamine for treatment of acute depression

Simon Hjerrild, Johannes Bjerre, Rasmus Hjuler Pedersen, Poul Videbech

3 Citations (Scopus)

Abstract

In clinical trials a single dose of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has shown a rapid antidepressant effect in patients with treatment-resistant depression and bipolar depression. The implications of glutaminergic mechanisms in depression and the rapid effect of a single dose of ketamine could open new pathways to understand the pathophysiology of depression and the development of novel rapid-acting antidepressant drugs.

Translated title of the contribution	Ketamine for treatment of acute depression
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	175
Issue number	37
Pages (from-to)	2090-3
Number of pages	4
ISSN	0041-5782
Publication status	Published - 9 Sept 2013
Externally published	Yes

Cite this

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title = "Ketamin til akut depressionsbehandling",

abstract = "In clinical trials a single dose of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has shown a rapid antidepressant effect in patients with treatment-resistant depression and bipolar depression. The implications of glutaminergic mechanisms in depression and the rapid effect of a single dose of ketamine could open new pathways to understand the pathophysiology of depression and the development of novel rapid-acting antidepressant drugs. ",

keywords = "Acute Disease, Analgesics, Short-Acting/administration \& dosage, Anesthetics, Dissociative/administration \& dosage, Antidepressive Agents/administration \& dosage, Bipolar Disorder/drug therapy, Depressive Disorder/drug therapy, Excitatory Amino Acid Antagonists/administration \& dosage, Humans, Ketamine/administration \& dosage, Placebos, Psychiatric Status Rating Scales, Randomized Controlled Trials as Topic, Receptors, N-Methyl-D-Aspartate/antagonists \& inhibitors, Treatment Outcome",

author = "Simon Hjerrild and Johannes Bjerre and Pedersen, \{Rasmus Hjuler\} and Poul Videbech",

year = "2013",

month = sep,

day = "9",

language = "Dansk",

volume = "175",

pages = "2090--3",

journal = "Ugeskrift for Laeger",

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publisher = "Almindelige Danske Laegeforening",

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TY - JOUR

T1 - Ketamin til akut depressionsbehandling

AU - Hjerrild, Simon

AU - Bjerre, Johannes

AU - Pedersen, Rasmus Hjuler

AU - Videbech, Poul

PY - 2013/9/9

Y1 - 2013/9/9

N2 - In clinical trials a single dose of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has shown a rapid antidepressant effect in patients with treatment-resistant depression and bipolar depression. The implications of glutaminergic mechanisms in depression and the rapid effect of a single dose of ketamine could open new pathways to understand the pathophysiology of depression and the development of novel rapid-acting antidepressant drugs.

AB - In clinical trials a single dose of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has shown a rapid antidepressant effect in patients with treatment-resistant depression and bipolar depression. The implications of glutaminergic mechanisms in depression and the rapid effect of a single dose of ketamine could open new pathways to understand the pathophysiology of depression and the development of novel rapid-acting antidepressant drugs.

KW - Acute Disease

KW - Analgesics, Short-Acting/administration & dosage

KW - Anesthetics, Dissociative/administration & dosage

KW - Antidepressive Agents/administration & dosage

KW - Bipolar Disorder/drug therapy

KW - Depressive Disorder/drug therapy

KW - Excitatory Amino Acid Antagonists/administration & dosage

KW - Humans

KW - Ketamine/administration & dosage

KW - Placebos

KW - Psychiatric Status Rating Scales

KW - Randomized Controlled Trials as Topic

KW - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors

KW - Treatment Outcome

UR - https://www.scopus.com/pages/publications/84890585963

M3 - Review

C2 - 24011203

SN - 0041-5782

VL - 175

SP - 2090

EP - 2093

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 37

ER -

Ketamin til akut depressionsbehandling

Abstract

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