Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{280c88876bc5406aa7087c647467aadd,
title = "KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes",
abstract = "The reduced incretin effect in subjects with type 2 diabetes is accompanied by a severely impaired insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). The K(ATP) channels of the beta-cell appear to be essential for the function of GIP in mice, and mutations in the gene encoding these channels have been linked to the development of type 2 diabetes. With this study we therefore aimed at clarifying the role of K(ATP) channel malfunction in the impaired function of GIP.",
author = "Kasper Aaboe and Knop, {Filip Krag} and Tina Vilsb{\o}ll and Aage V{\o}lund and Ulf Simonsen and Deacon, {Carolyn Fiona} and Sten Madsbad and Holst, {Jens Juul} and Thure Krarup",
year = "2009",
month = "2",
day = "1",
doi = "10.1210/jc.2008-1731",
language = "English",
volume = "94",
pages = "603--8",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The/Endocrine Society",
number = "2",

}

RIS

TY - JOUR

T1 - KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

AU - Aaboe, Kasper

AU - Knop, Filip Krag

AU - Vilsbøll, Tina

AU - Vølund, Aage

AU - Simonsen, Ulf

AU - Deacon, Carolyn Fiona

AU - Madsbad, Sten

AU - Holst, Jens Juul

AU - Krarup, Thure

PY - 2009/2/1

Y1 - 2009/2/1

N2 - The reduced incretin effect in subjects with type 2 diabetes is accompanied by a severely impaired insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). The K(ATP) channels of the beta-cell appear to be essential for the function of GIP in mice, and mutations in the gene encoding these channels have been linked to the development of type 2 diabetes. With this study we therefore aimed at clarifying the role of K(ATP) channel malfunction in the impaired function of GIP.

AB - The reduced incretin effect in subjects with type 2 diabetes is accompanied by a severely impaired insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). The K(ATP) channels of the beta-cell appear to be essential for the function of GIP in mice, and mutations in the gene encoding these channels have been linked to the development of type 2 diabetes. With this study we therefore aimed at clarifying the role of K(ATP) channel malfunction in the impaired function of GIP.

U2 - 10.1210/jc.2008-1731

DO - 10.1210/jc.2008-1731

M3 - Journal article

VL - 94

SP - 603

EP - 608

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 2

ER -

ID: 32266941