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The Capital Region of Denmark - a part of Copenhagen University Hospital
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KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

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The reduced incretin effect in subjects with type 2 diabetes is accompanied by a severely impaired insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). The K(ATP) channels of the beta-cell appear to be essential for the function of GIP in mice, and mutations in the gene encoding these channels have been linked to the development of type 2 diabetes. With this study we therefore aimed at clarifying the role of K(ATP) channel malfunction in the impaired function of GIP.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number2
Pages (from-to)603-8
Number of pages6
ISSN0021-972X
DOIs
Publication statusPublished - 1 Feb 2009

ID: 32266941