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The Capital Region of Denmark - a part of Copenhagen University Hospital
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JAK2-tree: a simple CBC-based decision rule to guide appropriate JAK2 V617F mutation testing

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AIMS: The JAK2 V617F mutation is highly recurrent in many of the myeloproliferative neoplasms, a molecular variant that can be easily detected using sensitive and minimally invasive techniques. Given the ease of JAK2 V617F testing, this test may be improperly requested for the purposes of patient 'screening' and to optimise laboratory resource utilisation, it behooves clinicians and laboratorians to perform JAK2 V617F testing only when most appropriate.

METHODS: To assist with the screening of patients being considered for JAK2 V617F testing, we developed a clinical decision rule, "JAK2-tree", which can be easily applied to basic CBC parameters (haemoglobin, platelet and white blood cell counts).

RESULTS: We tested JAK2-tree on two independent datasets, one an unselected population-based sample (the Copenhagen General Population Study) and the other an historical clinical laboratory referral set, with sensitivities for JAK2 V617F detection of 91% and 94%, respectively. As applied to the historical laboratory referral dataset, moreover, the JAK2-tree algorithm would have reduced JAK2 V617F testing volume over the period of evaluation by 15%.

CONCLUSIONS: Our work supports a simple decision-tree-based screening approach to optimize the selection of patients most appropriate for JAK2 V617F testing.

Original languageEnglish
JournalJournal of Clinical Pathology
Volume72
Issue number2
Pages (from-to)172-176
Number of pages5
ISSN0021-9746
DOIs
Publication statusPublished - Feb 2019

    Research areas

  • Adult, Aged, Aged, 80 and over, Blood Cell Count, DNA Mutational Analysis/methods, Decision Trees, Female, Humans, Janus Kinase 2/genetics, Male, Middle Aged, Myeloproliferative Disorders/diagnosis, Young Adult

ID: 56639076