J-refocused semi-LASER spectroscopy at 7T: proof-of-concept and application in the human brain at 7T

Chloe Najac; Vincent Oltman Boer; Hermien E Kan; Andrew G Webb; Itamar Ronen

J-refocused semi-LASER spectroscopy at 7T: proof-of-concept and application in the human brain at 7T

Chloe Najac, Vincent Oltman Boer, Hermien E Kan, Andrew G Webb, Itamar Ronen

Abstract

Spin-echo sequences suffer from loss of signal due to J-modulation for coupled spins. Previously, it was shown that adding a π/2 pulse between two π pulses in a double spin-echo sequence partially refocuses some of the J-evolution. However, the potential of such sequence at ultrahigh field is limited due to the large chemical shift displacement error. Here, we propose a J-refocused variant of the sLASER sequence (J-sLASER) to improve quantification of J-coupled metabolites at ultrahigh field. Significant improvement in quantitation of J-coupled metabolites is illustrated using simulation, phantom and in vivo measurements in the human brain.

Original language	English
Title of host publication	Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages	3
Publisher	The International Society for Magnetic Resonance in Medicine
Publication date	2020
Pages	1-3
Article number	2858
Publication status	Published - 2020
Event	ISMRM & SMRT Virtual Conference & Exhibition 2020 - Virtual conference Duration: 8 Aug 2020 → 14 Aug 2020 https://www.ismrm.org/20m/

Conference

Conference	ISMRM & SMRT Virtual Conference & Exhibition 2020
Location	Virtual conference
Period	08/08/2020 → 14/08/2020
Internet address	https://www.ismrm.org/20m/

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J-refocused semi-LASER spectroscopy at 7T: proof-of-concept and application in the human brain at 7T. / Najac, Chloe; Boer, Vincent Oltman; Kan, Hermien E et al.
Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition. The International Society for Magnetic Resonance in Medicine, 2020. p. 1-3 2858.

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review

Najac, C, Boer, VO, Kan, HE, Webb, AG & Ronen, I 2020, J-refocused semi-LASER spectroscopy at 7T: proof-of-concept and application in the human brain at 7T. in Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition., 2858, The International Society for Magnetic Resonance in Medicine, pp. 1-3, ISMRM & SMRT Virtual Conference & Exhibition 2020, 08/08/2020. <https://archive.ismrm.org/2020/2858.html>

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title = "J-refocused semi-LASER spectroscopy at 7T: proof-of-concept and application in the human brain at 7T",

abstract = "Spin-echo sequences suffer from loss of signal due to J-modulation for coupled spins. Previously, it was shown that adding a π/2 pulse between two π pulses in a double spin-echo sequence partially refocuses some of the J-evolution. However, the potential of such sequence at ultrahigh field is limited due to the large chemical shift displacement error. Here, we propose a J-refocused variant of the sLASER sequence (J-sLASER) to improve quantification of J-coupled metabolites at ultrahigh field. Significant improvement in quantitation of J-coupled metabolites is illustrated using simulation, phantom and in vivo measurements in the human brain.",

author = "Chloe Najac and Boer, \{Vincent Oltman\} and Kan, \{Hermien E\} and Webb, \{Andrew G\} and Itamar Ronen",

year = "2020",

language = "English",

pages = "1--3",

booktitle = "Proceedings of the 2020 ISMRM \& SMRT Virtual Conference \& Exhibition",

publisher = "The International Society for Magnetic Resonance in Medicine",

note = "ISMRM \& SMRT Virtual Conference \& Exhibition 2020 ; Conference date: 08-08-2020 Through 14-08-2020",

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T1 - J-refocused semi-LASER spectroscopy at 7T: proof-of-concept and application in the human brain at 7T

AU - Najac, Chloe

AU - Boer, Vincent Oltman

AU - Kan, Hermien E

AU - Webb, Andrew G

AU - Ronen, Itamar

PY - 2020

Y1 - 2020

N2 - Spin-echo sequences suffer from loss of signal due to J-modulation for coupled spins. Previously, it was shown that adding a π/2 pulse between two π pulses in a double spin-echo sequence partially refocuses some of the J-evolution. However, the potential of such sequence at ultrahigh field is limited due to the large chemical shift displacement error. Here, we propose a J-refocused variant of the sLASER sequence (J-sLASER) to improve quantification of J-coupled metabolites at ultrahigh field. Significant improvement in quantitation of J-coupled metabolites is illustrated using simulation, phantom and in vivo measurements in the human brain.

AB - Spin-echo sequences suffer from loss of signal due to J-modulation for coupled spins. Previously, it was shown that adding a π/2 pulse between two π pulses in a double spin-echo sequence partially refocuses some of the J-evolution. However, the potential of such sequence at ultrahigh field is limited due to the large chemical shift displacement error. Here, we propose a J-refocused variant of the sLASER sequence (J-sLASER) to improve quantification of J-coupled metabolites at ultrahigh field. Significant improvement in quantitation of J-coupled metabolites is illustrated using simulation, phantom and in vivo measurements in the human brain.

M3 - Conference abstract in proceedings

SP - 1

EP - 3

BT - Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition

PB - The International Society for Magnetic Resonance in Medicine

T2 - ISMRM & SMRT Virtual Conference & Exhibition 2020

Y2 - 8 August 2020 through 14 August 2020

ER -

J-refocused semi-LASER spectroscopy at 7T: proof-of-concept and application in the human brain at 7T

Abstract

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