TY - JOUR
T1 - Isoniazidinduceret toksisk hepatitis
AU - Kristensen, Kristina Langholz
AU - Nordholm, Anne Christine
AU - Clausen, Mette Rye
AU - Katzenstein, Terese L
PY - 2021/2/8
Y1 - 2021/2/8
N2 - Hepatotoxicity is a well-known side effect to isoniazid treatment with the risk of progression to liver failure. This case report describes a 39-year-old male, who received standard isoniazid treatment for latent TB infection (LTBI) and developed severe isoniazid-induced acute hepatitis. Liver transplantation was considered, but the patient slowly recovered with full hepatic regeneration. With increasing focus on treating LTBI in Denmark, routine follow-up including biochemical monitoring should be implemented for patients receiving LTBI treatment to prevent severe complications.
AB - Hepatotoxicity is a well-known side effect to isoniazid treatment with the risk of progression to liver failure. This case report describes a 39-year-old male, who received standard isoniazid treatment for latent TB infection (LTBI) and developed severe isoniazid-induced acute hepatitis. Liver transplantation was considered, but the patient slowly recovered with full hepatic regeneration. With increasing focus on treating LTBI in Denmark, routine follow-up including biochemical monitoring should be implemented for patients receiving LTBI treatment to prevent severe complications.
KW - Adult
KW - Antitubercular Agents/adverse effects
KW - Hepatitis/drug therapy
KW - Humans
KW - Isoniazid/adverse effects
KW - Latent Tuberculosis/drug therapy
KW - Male
M3 - Tidsskriftartikel
C2 - 33570026
SN - 0041-5782
VL - 183
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
IS - 6
ER -