Abstract
The regional, intraarterial, injection of CCK-8 elicits reciprocal effects on the motility of the extrahepatic biliary tree in the cat: the contraction of the gallbladder and a relaxation of the sphincter of Oddi as well as of the duodenal wall. After neural blockade with tetrodotoxin the responses of the sphincter to CCK-8 were blocked, and the responses of the gallbladder were markedly reduced. After the regional administration of a VIP antiserum the sphincter relaxation in response to CCK-8 was blocked. Immunocytochemically it was demonstrated that the feline sphincter contains a rich VIP-ergic innervation, while CCK-like immunoreactivity was found only in mucosal endocrine cells. The results indicate that CCK-8 selectively activates inhibitory VIP neurons innervating the sphincter. After the administration of a nonpeptide CCK-receptor antagonist, the CCK-8 induced motor responses of both the sphincter and the gallbladder were markedly reduced. This indicates that blockade of CCK-8 receptors involves muscular as well as neural CCK-receptors.
| Original language | English |
|---|---|
| Journal | Journal of the Autonomic Nervous System |
| Volume | 31 |
| Issue number | 1 |
| Pages (from-to) | 75-84 |
| Number of pages | 10 |
| ISSN | 0165-1838 |
| DOIs | |
| Publication status | Published - Sept 1990 |
| Externally published | Yes |
Keywords
- Animals
- Benzodiazepinones/pharmacology
- Cats
- Devazepide
- Female
- Immune Sera/immunology
- Immunohistochemistry
- Male
- Muscle Relaxation
- Nerve Block
- Neurons/physiology
- Sincalide/antagonists & inhibitors
- Sphincter of Oddi/drug effects
- Tetrodotoxin/pharmacology
- Vasoactive Intestinal Peptide/antagonists & inhibitors
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