Is pancreatic polypeptide response to food ingestion a reliable index of vagal function in type 1 diabetes?

M B Damholt, P Arlien-Soeborg, L Hilsted, J Hilsted

3 Citations (Scopus)

Abstract

The diagnosis of autonomic neuropathy in diabetic patients is based on cardiovascular reflex tests. Since cardiac function may be affected by arteriosclerosis and cardiomyopathy in type 1 diabetes mellitus, alternative tests reflecting vagal nerve function, in other organ systems, are needed. In this study the pancreatic polypeptide (PP) response to a mixed meal was evaluated in healthy subjects and in recently diagnosed type 1 diabetic patients.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume66
Issue number4
Pages (from-to)279-86
Number of pages8
ISSN0036-5513
DOIs
Publication statusPublished - 2006

Keywords

  • Adult
  • Analysis of Variance
  • Area Under Curve
  • Arginine
  • Biological Markers
  • Cholinesterase Inhibitors
  • Diabetes Mellitus, Type 1
  • Diabetic Neuropathies
  • Eating
  • Edrophonium
  • Female
  • Humans
  • Male
  • Pancreatic Polypeptide
  • Vagus Nerve Diseases

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