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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Is infertility after surgery for cryptorchidism congenital or acquired?

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  1. Gonocyte transformation in congenital undescended testes: what is the role of inhibin-B in cell death?

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  2. The relation of germ cells per tubule in testes, serum inhibin B and FSH in cryptorchid boys

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  3. The incidence of maldescended testes in Denmark

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  1. Newborn body composition after maternal bariatric surgery

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  2. Review of injection techniques for spermatogonial stem cell transplantation

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We evaluated whether deletions of the DAZ (deleted in azoospermia) gene, abnormal karyotypes or hypogonadotropic hypogonadism (HH) were demonstrable in infertile men who had undergone surgery in childhood for cryptorchidism with a simultaneous testicular biopsy that demonstrated no or almost no germ cells. In six men with infertility after surgery for cryptorchidism, the adult karyotype and analyses for the DAZ gene, serum follicle-stimulating hormone, luteinizing hormone, and testosterone were performed from a peripheral blood sample. Testicular volume was also measured. All patients exhibited a 46,XY karyotype. There were no deletions of the DAZ-gene, no HH and no testicular atrophy. The infertility was thus not proved to be congenital, and consequently, surgical treatment is indicated before the germ cells disappear from undescended testes. This appears to be before 15 months of age.

Original languageEnglish
JournalPediatric Surgery International
Volume14
Issue number1-2
Pages (from-to)6-8
Number of pages3
ISSN0179-0358
Publication statusPublished - Nov 1998

    Research areas

  • Adult, Cryptorchidism, Gene Deletion, Humans, Infertility, Male, Karyotyping, Male, Oligospermia, Testis

ID: 46508851