Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

In-vitro Recordings of Neural Magnetic Activity From the Auditory Brainstem Using Color Centers in Diamond: A Simulation Study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reduction of Pressure Pain Sensitivity as Novel Non-pharmacological Therapeutic Approach to Type 2 Diabetes: A Randomized Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Feasibility of Glutamate and GABA Detection in Pons and Thalamus at 3T and 7T by Proton Magnetic Resonance Spectroscopy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Untreated Patients Dying With AIDS Have Loss of Neocortical Neurons and Glia Cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Detection of biological signals from a live mammalian muscle using an early stage diamond quantum sensor

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Interindividual variability of electric fields during transcranial temporal interference stimulation (tTIS)

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Estimation of individually induced e-field strength during transcranial electric stimulation using the head circumference

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Concurrent TMS-fMRI for causal network perturbation and proof of target engagement

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Safety Evaluation of a New Setup for Transcranial Electric Stimulation during Magnetic Resonance Imaging

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Mürsel Karadas
  • Christoffer Olsson
  • Nikolaj Winther Hansen
  • Jean-François Perrier
  • James Luke Webb
  • Alexander Huck
  • Ulrik Lund Andersen
  • Axel Thielscher
View graph of relations

Magnetometry based on nitrogen-vacancy (NV) centers in diamond is a novel technique capable of measuring magnetic fields with high sensitivity and high spatial resolution. With the further advancements of these sensors, they may open up novel approaches for the 2D imaging of neural signals in vitro. In the present study, we investigate the feasibility of NV-based imaging by numerically simulating the magnetic signal from the auditory pathway of a rodent brainstem slice (ventral cochlear nucleus, VCN, to the medial trapezoid body, MNTB) as stimulated by both electric and optic stimulation. The resulting signal from these two stimulation methods are evaluated and compared. A realistic pathway model was created based on published data of the neural morphologies and channel dynamics of the globular bushy cells in the VCN and their axonal projections to the principal cells in the MNTB. The pathway dynamics in response to optic and electric stimulation and the emitted magnetic fields were estimated using the cable equation. For simulating the optic stimulation, the light distribution in brain tissue was numerically estimated and used to model the optogenetic neural excitation based on a four state channelrhodopsin-2 (ChR2) model. The corresponding heating was also estimated, using the bio-heat equation and was found to be low (<2°C) even at excessively strong optic signals. A peak magnetic field strength of ∼0.5 and ∼0.1 nT was calculated from the auditory brainstem pathway after electrical and optical stimulation, respectively. By increasing the stimulating light intensity four-fold (far exceeding commonly used intensities) the peak magnetic signal strength only increased to 0.2 nT. Thus, while optogenetic stimulation would be favorable to avoid artefacts in the recordings, electric stimulation achieves higher peak fields. The present simulation study predicts that high-resolution magnetic imaging of the action potentials traveling along the auditory brainstem pathway will only be possible for next generation NV sensors. However, the existing sensors already have sufficient sensitivity to support the magnetic sensing of cumulated neural signals sampled from larger parts of the pathway, which might be a promising intermediate step toward further maturing this novel technology.

Original languageEnglish
Article number643614
JournalFrontiers in Neuroscience
Volume15
Pages (from-to)1-17
Number of pages17
ISSN1662-4548
DOIs
Publication statusPublished - 13 May 2021

    Research areas

  • Kubelka-Munk model, Monte Carlo, NV centers, cable equation, fiber optics, magnetometry, neural magnetic field, optogenetics

ID: 65945283