Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers

K Buschard; C Kühl; L Mølsted-Pedersen; E Lund; J Palmer; G F Bottazzo

doi:10.1016/s0140-6736(89)92272-1

Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers

K Buschard, C Kühl, L Mølsted-Pedersen, E Lund, J Palmer, G F Bottazzo

7 Citations (Scopus)

Abstract

55 children who were in utero when type 1 diabetes developed in their mothers were studied at a mean (SEM) age of 10.4 (0.6) years: only 1 was diabetic. Biochemical and immunological indices, measured in 35 children, showed no evidence of beta cell dysfunction. Thus, the fetal beta cells seem to be unaffected by the mechanisms that cause diabetes in their mothers.

Original language	English
Journal	Lancet
Volume	1
Issue number	8642
Pages (from-to)	811-4
Number of pages	4
ISSN	0140-6736
DOIs	https://doi.org/10.1016/s0140-6736(89)92272-1
Publication status	Published - 15 Apr 1989
Externally published	Yes

Keywords

Adolescent
Adult
Antibodies/analysis
Autoantibodies/analysis
Child
Child, Preschool
Cohort Studies
Denmark
Diabetes Mellitus, Type 1/drug therapy
Female
Fetus
Follow-Up Studies
Humans
Immunoglobulin G/analysis
Insulin/immunology
Islets of Langerhans/immunology
Pancreas/cytology
Pregnancy
Pregnancy in Diabetics/drug therapy
Prognosis

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10.1016/s0140-6736(89)92272-1

Cite this

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title = "Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers",

abstract = "55 children who were in utero when type 1 diabetes developed in their mothers were studied at a mean (SEM) age of 10.4 (0.6) years: only 1 was diabetic. Biochemical and immunological indices, measured in 35 children, showed no evidence of beta cell dysfunction. Thus, the fetal beta cells seem to be unaffected by the mechanisms that cause diabetes in their mothers.",

keywords = "Adolescent, Adult, Antibodies/analysis, Autoantibodies/analysis, Child, Child, Preschool, Cohort Studies, Denmark, Diabetes Mellitus, Type 1/drug therapy, Female, Fetus, Follow-Up Studies, Humans, Immunoglobulin G/analysis, Insulin/immunology, Islets of Langerhans/immunology, Pancreas/cytology, Pregnancy, Pregnancy in Diabetics/drug therapy, Prognosis",

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doi = "10.1016/s0140-6736(89)92272-1",

language = "English",

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T1 - Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers

AU - Buschard, K

AU - Kühl, C

AU - Mølsted-Pedersen, L

AU - Lund, E

AU - Palmer, J

AU - Bottazzo, G F

PY - 1989/4/15

Y1 - 1989/4/15

N2 - 55 children who were in utero when type 1 diabetes developed in their mothers were studied at a mean (SEM) age of 10.4 (0.6) years: only 1 was diabetic. Biochemical and immunological indices, measured in 35 children, showed no evidence of beta cell dysfunction. Thus, the fetal beta cells seem to be unaffected by the mechanisms that cause diabetes in their mothers.

AB - 55 children who were in utero when type 1 diabetes developed in their mothers were studied at a mean (SEM) age of 10.4 (0.6) years: only 1 was diabetic. Biochemical and immunological indices, measured in 35 children, showed no evidence of beta cell dysfunction. Thus, the fetal beta cells seem to be unaffected by the mechanisms that cause diabetes in their mothers.

KW - Adolescent

KW - Adult

KW - Antibodies/analysis

KW - Autoantibodies/analysis

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Denmark

KW - Diabetes Mellitus, Type 1/drug therapy

KW - Female

KW - Fetus

KW - Follow-Up Studies

KW - Humans

KW - Immunoglobulin G/analysis

KW - Insulin/immunology

KW - Islets of Langerhans/immunology

KW - Pancreas/cytology

KW - Pregnancy

KW - Pregnancy in Diabetics/drug therapy

KW - Prognosis

UR - https://www.scopus.com/pages/publications/0024524369

U2 - 10.1016/s0140-6736(89)92272-1

DO - 10.1016/s0140-6736(89)92272-1

M3 - Journal article

C2 - 2564904

SN - 0140-6736

VL - 1

SP - 811

EP - 814

JO - Lancet

JF - Lancet

IS - 8642

ER -

Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers

Abstract

Keywords

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