Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Novel functions of the luteinizing hormone/chorionic gonadotropin receptor in prostate cancer cells and patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hepatitis C prevalence in Denmark in 2016-An updated estimate using multiple national registers

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Lipidomics of human adipose tissue reveals diversity between body areas

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Functional gene networks reveal distinct mechanisms segregating in migraine families

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The Duffy-null genotype and risk of infection

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Letter to the editor regarding "Have you ever experienced a headache of any kind?"

    Research output: Contribution to journalLetterResearchpeer-review

  5. Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Eske M Derks
  • Jacob A S Vorstman
  • Stephan Ripke
  • Rene S Kahn
  • Roel A Ophoff
  • Schizophrenia Psychiatric Genomic Consortium
View graph of relations
The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p
Original languageEnglish
JournalP L o S One
Volume7
Issue number6
Pages (from-to)e37852
ISSN1932-6203
DOIs
Publication statusPublished - 2012

    Research areas

  • Case-Control Studies, DNA, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Multifactorial Inheritance, Netherlands, Phenotype, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Prognosis, Psychotic Disorders, Risk Factors, Schizophrenia

ID: 38674116