Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis

Sophine B Krintel; Giuseppe Palermo; Julia S Johansen; Søren Germer; Laurent Essioux; Ryma Benayed; Laura Badi; Mikkel Østergaard; Merete L Hetland

doi:10.1097/FPC.0b013e3283544043

Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis

Sophine B Krintel, Giuseppe Palermo, Julia S Johansen, Søren Germer, Laurent Essioux, Ryma Benayed, Laura Badi, Mikkel Østergaard, Merete L Hetland

Oncology

61 Citations (Scopus)

Abstract

Recently, two genome-wide association studies identified single nucleotide polymorphisms (SNPs) significantly associated with the treatment response to tumor necrosis factor α (TNFα) inhibitors in patients with rheumatoid arthritis (RA). We aimed to replicate these results and identify SNPs and the possible biological pathways associated with the treatment response to TNFα inhibitors.

Original language	English
Journal	Pharmacogenetics and Genomics
Volume	22
Issue number	8
Pages (from-to)	577-89
Number of pages	13
ISSN	1744-6872
DOIs	https://doi.org/10.1097/FPC.0b013e3283544043
Publication status	Published - 2012

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Krintel, S. B., Palermo, G., Johansen, J. S., Germer, S., Essioux, L., Benayed, R., Badi, L., Østergaard, M., & Hetland, M. L. (2012). Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis. Pharmacogenetics and Genomics, 22(8), 577-89. https://doi.org/10.1097/FPC.0b013e3283544043

Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis. / Krintel, Sophine B; Palermo, Giuseppe; Johansen, Julia S et al.

In: Pharmacogenetics and Genomics, Vol. 22, No. 8, 2012, p. 577-89.

Research output: Contribution to journal › Journal article › Research › peer-review

Krintel, SB, Palermo, G, Johansen, JS, Germer, S, Essioux, L, Benayed, R, Badi, L, Østergaard, M & Hetland, ML 2012, 'Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis', Pharmacogenetics and Genomics, vol. 22, no. 8, pp. 577-89. https://doi.org/10.1097/FPC.0b013e3283544043

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AU - Krintel, Sophine B

AU - Palermo, Giuseppe

AU - Johansen, Julia S

AU - Germer, Søren

AU - Essioux, Laurent

AU - Benayed, Ryma

AU - Badi, Laura

AU - Østergaard, Mikkel

AU - Hetland, Merete L

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AB - Recently, two genome-wide association studies identified single nucleotide polymorphisms (SNPs) significantly associated with the treatment response to tumor necrosis factor α (TNFα) inhibitors in patients with rheumatoid arthritis (RA). We aimed to replicate these results and identify SNPs and the possible biological pathways associated with the treatment response to TNFα inhibitors.

U2 - 10.1097/FPC.0b013e3283544043

DO - 10.1097/FPC.0b013e3283544043

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JF - Pharmacogenetics and Genomics

SN - 1744-6872

IS - 8

ER -

Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis

Abstract

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