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Investigation of anti-Müllerian hormone concentrations in relation to natural conception rate and time to pregnancy

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@article{d7bb50462eec4b50a5581de4ca83aaf7,
title = "Investigation of anti-M{\"u}llerian hormone concentrations in relation to natural conception rate and time to pregnancy",
abstract = "The objectives of this study were to investigate whether anti-M{\"u}llerian hormone (AMH) concentrations can predict pregnancy rates and time to pregnancy (TTP) in women attempting to conceive naturally/having an unplanned conception, and whether there is a lower AMH threshold compatible with natural conception. This prospective cohort study included 260 women aged 25-42 years in two subcohorts: (A) healthcare workers at Rigshospitalet (2008-2010), and (B) women consulting the Fertility Assessment and Counselling Clinic (2011-2014), Rigshospitalet, Denmark. Pregnancy rates and TTP at 2-year follow-up were stratified into AMH groups: low: < 9.5 pmol/l, intermediate: 9.5-33 pmol/l, high: > 33 pmol/l. Pregnancy rates increased with increasing AMH: 60.1% (low) versus 70.0% (intermediate) versus 78.3% (high) (P = 0.03). The highest pregnancy rate (84.1%) was seen in regular cycling women with high AMH. TTP was reduced in women with high AMH compared with intermediate or low AMH (stepwise trend test P = 0.01). Natural conceptions were observed with AMH concentrations down to 1.2 pmol/l. In conclusion, high AMH, especially in ovulatory women, was associated with higher pregnancy rates. Nonetheless, TTP reflected a large variation in fecundity within similar AMH concentrations and natural conceptions occurred with AMH down to 1.2 pmol/l.",
keywords = "Adult, Anti-Mullerian Hormone/blood, Female, Fertilization, Humans, Pregnancy, Pregnancy Rate, Time-to-Pregnancy",
author = "Anne-Sofie Korsholm and Petersen, {Kathrine Birch} and Bentzen, {Janne Gasseholm} and Hilsted, {Linda Maria} and Andersen, {Anders Nyboe} and Hvidman, {Helene Westring}",
note = "Copyright {\textcopyright} 2018 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.",
year = "2018",
month = may,
doi = "10.1016/j.rbmo.2018.01.013",
language = "English",
volume = "36",
pages = "568--575",
journal = "Reproductive BioMedicine Online",
issn = "1472-6483",
publisher = "Reproductive Healthcare Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Investigation of anti-Müllerian hormone concentrations in relation to natural conception rate and time to pregnancy

AU - Korsholm, Anne-Sofie

AU - Petersen, Kathrine Birch

AU - Bentzen, Janne Gasseholm

AU - Hilsted, Linda Maria

AU - Andersen, Anders Nyboe

AU - Hvidman, Helene Westring

N1 - Copyright © 2018 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

PY - 2018/5

Y1 - 2018/5

N2 - The objectives of this study were to investigate whether anti-Müllerian hormone (AMH) concentrations can predict pregnancy rates and time to pregnancy (TTP) in women attempting to conceive naturally/having an unplanned conception, and whether there is a lower AMH threshold compatible with natural conception. This prospective cohort study included 260 women aged 25-42 years in two subcohorts: (A) healthcare workers at Rigshospitalet (2008-2010), and (B) women consulting the Fertility Assessment and Counselling Clinic (2011-2014), Rigshospitalet, Denmark. Pregnancy rates and TTP at 2-year follow-up were stratified into AMH groups: low: < 9.5 pmol/l, intermediate: 9.5-33 pmol/l, high: > 33 pmol/l. Pregnancy rates increased with increasing AMH: 60.1% (low) versus 70.0% (intermediate) versus 78.3% (high) (P = 0.03). The highest pregnancy rate (84.1%) was seen in regular cycling women with high AMH. TTP was reduced in women with high AMH compared with intermediate or low AMH (stepwise trend test P = 0.01). Natural conceptions were observed with AMH concentrations down to 1.2 pmol/l. In conclusion, high AMH, especially in ovulatory women, was associated with higher pregnancy rates. Nonetheless, TTP reflected a large variation in fecundity within similar AMH concentrations and natural conceptions occurred with AMH down to 1.2 pmol/l.

AB - The objectives of this study were to investigate whether anti-Müllerian hormone (AMH) concentrations can predict pregnancy rates and time to pregnancy (TTP) in women attempting to conceive naturally/having an unplanned conception, and whether there is a lower AMH threshold compatible with natural conception. This prospective cohort study included 260 women aged 25-42 years in two subcohorts: (A) healthcare workers at Rigshospitalet (2008-2010), and (B) women consulting the Fertility Assessment and Counselling Clinic (2011-2014), Rigshospitalet, Denmark. Pregnancy rates and TTP at 2-year follow-up were stratified into AMH groups: low: < 9.5 pmol/l, intermediate: 9.5-33 pmol/l, high: > 33 pmol/l. Pregnancy rates increased with increasing AMH: 60.1% (low) versus 70.0% (intermediate) versus 78.3% (high) (P = 0.03). The highest pregnancy rate (84.1%) was seen in regular cycling women with high AMH. TTP was reduced in women with high AMH compared with intermediate or low AMH (stepwise trend test P = 0.01). Natural conceptions were observed with AMH concentrations down to 1.2 pmol/l. In conclusion, high AMH, especially in ovulatory women, was associated with higher pregnancy rates. Nonetheless, TTP reflected a large variation in fecundity within similar AMH concentrations and natural conceptions occurred with AMH down to 1.2 pmol/l.

KW - Adult

KW - Anti-Mullerian Hormone/blood

KW - Female

KW - Fertilization

KW - Humans

KW - Pregnancy

KW - Pregnancy Rate

KW - Time-to-Pregnancy

U2 - 10.1016/j.rbmo.2018.01.013

DO - 10.1016/j.rbmo.2018.01.013

M3 - Journal article

C2 - 29478840

VL - 36

SP - 568

EP - 575

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 5

ER -

ID: 55782417