Investigating the Link between Psoriasis and Cardiovascular Disease: Current Evidence, Therapeutic Implications and Perspectives

Eirini Kapniari, Prokopios Papadimitriou, Marianna Dalamaga, George Makavos, Stefano Piaserico, Alexander Egeberg, Ignatios Ikonomidis, Evangelia Papadavid

6 Citations (Scopus)


Psoriasis; a chronic inflammatory disease is characterized by symmetric hyperkeratotic plaques affecting any part of the body. Psoriasis is nowadays considered as a systemic inflammation linked with several comorbidities as metabolic syndrome, depression, anxiety and increased prevalence of cardiovascular (CV) disease. The hypothesis that psoriasis is an independent CV risk factor leading to atherosclerosis via inflammation is now widely accepted. Deciphering the underlying mechanisms interconnecting psoriasis and CV disease may have significant implications in treatment decisions. Accumulating evidence suggests that systematic therapies and recently introduced biologic agents, that control psoriasis by suppressing the chronic and systemic inflammation, may alter the progression of CV disease. We herein attempt a review of current evidence analysing the relationship between psoriasis and CV comorbidities, comment on the mechanisms underlying this association and investigate the consequences for the management of psoriasis.

Original languageEnglish
JournalCurrent Vascular Pharmacology
Issue number6
Pages (from-to)592-609
Number of pages18
Publication statusPublished - 2020


  • Anti-inflammatory agents
  • Biologics
  • Cardiovascular diseases
  • Inflammation
  • Psoriasis
  • Skin disease
  • Prognosis
  • Risk Assessment
  • Cardiovascular Diseases/epidemiology
  • Humans
  • Psoriasis/drug therapy
  • Anti-Inflammatory Agents/adverse effects
  • Arthritis, Psoriatic/drug therapy
  • Animals
  • Antirheumatic Agents/adverse effects
  • Heart Disease Risk Factors
  • Inflammation/drug therapy
  • Immunocompromised Host
  • biologics
  • skin disease
  • cardiovascular diseases
  • inflammation
  • anti-inflammatory agents


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