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Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies

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PURPOSE: The discovery of musculoskeletal tissues, including muscle, tendons, and cartilage, as peripheral circadian clocks strongly implicates their role in tissue-specific homeostasis. Age-related dampening and misalignment of the tendon circadian rhythm and its outputs may be responsible for the decline in tendon homeostasis. It is unknown which entrainment signals are responsible for the synchronization of the tendon clock to the light-dark cycle.

METHODS: We sought to examine any changes in the expression levels of core clock genes (BMAL1, CLOCK, PER2, CRY1, and NR1D1) in healthy human patellar tendon biopsies obtained from three different intervention studies: increased physical activity (leg kicks for 1 h) in young, reduced activity (2 weeks immobilization of one leg) in young, and in old tendons.

RESULTS: The expression level of clock genes in human tendon in vivo was very low and a high variation between individuals was found. We were thus unable to detect any differences in core clock gene expression neither after acute exercise nor immobilization.

CONCLUSIONS: We are unable to find evidence for an effect of exercise or immobilization on circadian clock gene expression in human tendon samples.

Original languageEnglish
JournalEuropean Journal of Applied Physiology
Volume119
Issue number6
Pages (from-to)1387-1394
Number of pages8
ISSN1439-6319
DOIs
Publication statusPublished - Jun 2019

    Research areas

  • Adult, Aged, Circadian Rhythm Signaling Peptides and Proteins/genetics, Exercise, Humans, Immobilization/adverse effects, Male, Patellar Ligament/growth & development

ID: 59363134