TY - JOUR
T1 - Invasive procedures and risk of brain abscess
T2 - a nationwide, population-based case-control study
AU - Omland, Lars Haukali
AU - Bodilsen, Jacob
AU - Helweg-Larsen, Jannik
AU - Jarløv, Jens Otto
AU - Andreasen, Kristian
AU - Ziebell, Morten
AU - Ellermann-Eriksen, Svend
AU - Justesen, Ulrik S
AU - Frimodt-Møller, Niels
AU - Obel, Niels
PY - 2023
Y1 - 2023
N2 - OBJECTIVES: It is unknown whether invasive procedures are associated with brain abscess.METHODS: Nationwide, population-based, matched case-control study of patients with culture verified brain abscess in Denmark from 1989 to 2016. Exposure was invasive procedures 0-6 months before study inclusion.RESULTS: We identified 435 patients and 3909 controls. The level of comorbidity was higher among patients with brain abscess than among controls. A total of 48 cases (11%) had one or more invasive procedures 0-6 months before study inclusion (adjusted odds ratios (aOR) of 3.6 (95% confidence interval (CI): 2.5-5.1), a population attributable fractions of 8% (95% CI: 7-9)). In primary care, ear, nose and throat (ENT) procedures were associated with brain abscess (aOR of 4.0 (95% CI: 2.0-8.0)), but gastrointestinal endoscopies were not (aOR of 1.0 (95% CI: 0.3-3.2)). No bronchoscopies were performed in primary care. In the hospital-based setting, ENT procedures, bronchoscopies and gastrointestinal endoscopies were associated with an increased risk of brain abscess (aOR of 14.5 (95% CI: 4.8-43.8), 20.3 (95% CI: 3.8-110.1) and 3.4 (95% CI: 2.0-5.6), respectively).CONCLUSIONS: The association between invasive procedures and brain abscess was more pronounced in the hospital-based setting than in primary care.
AB - OBJECTIVES: It is unknown whether invasive procedures are associated with brain abscess.METHODS: Nationwide, population-based, matched case-control study of patients with culture verified brain abscess in Denmark from 1989 to 2016. Exposure was invasive procedures 0-6 months before study inclusion.RESULTS: We identified 435 patients and 3909 controls. The level of comorbidity was higher among patients with brain abscess than among controls. A total of 48 cases (11%) had one or more invasive procedures 0-6 months before study inclusion (adjusted odds ratios (aOR) of 3.6 (95% confidence interval (CI): 2.5-5.1), a population attributable fractions of 8% (95% CI: 7-9)). In primary care, ear, nose and throat (ENT) procedures were associated with brain abscess (aOR of 4.0 (95% CI: 2.0-8.0)), but gastrointestinal endoscopies were not (aOR of 1.0 (95% CI: 0.3-3.2)). No bronchoscopies were performed in primary care. In the hospital-based setting, ENT procedures, bronchoscopies and gastrointestinal endoscopies were associated with an increased risk of brain abscess (aOR of 14.5 (95% CI: 4.8-43.8), 20.3 (95% CI: 3.8-110.1) and 3.4 (95% CI: 2.0-5.6), respectively).CONCLUSIONS: The association between invasive procedures and brain abscess was more pronounced in the hospital-based setting than in primary care.
UR - http://www.scopus.com/inward/record.url?scp=85140076877&partnerID=8YFLogxK
U2 - 10.1080/23744235.2022.2132284
DO - 10.1080/23744235.2022.2132284
M3 - Journal article
C2 - 36239458
VL - 55
SP - 55
EP - 62
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 1
ER -