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Intubation conditions after rocuronium or succinylcholine for rapid sequence induction with alfentanil and propofol in the emergency patient

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Background and objective: Previous studies mainly conducted on elective patients recommend doses of 0.9-1.2 mg kg[-1] rocuronium to obtain comparable intubation conditions with succinylcholine 1.0 mg kg[-1] after 60 s during a rapid-sequence induction. We decided to compare the overall intubating conditions of standard doses of rocuronium 0.6 mg kg[-1] and succinylcholine 1.0 mg kg[-1] during a strict rapid-sequence induction regimen including propofol and alfentanil. Methods: Male and female patients (ASA I-III) older than 17 yr scheduled for emergency abdominal or gynaecological surgery and with increased risk of pulmonary aspiration of gastric content were randomized to a rapid-sequence induction with succinylcholine 1.0 mg kg[-1] or rocuronium 0.6 mg kg[-1]. Patients with a predicted difficult airway were excluded. A senior anaesthesiologist 'blinded' for the randomization performed the intubation 60 s after injection of the neuromuscular blocker. Intubating conditions were evaluated according to an established guideline. Tracheal intubation not completed within 30 s was recorded as failed. Results: 222 patients were randomized. Three patients had their operation cancelled and 10 did not fulfil the inclusion criteria. Clinically acceptable intubation conditions were present in 93.5% and 96.1% of patients in the succinylcholine group (n=107) and the rocuronium group (n=102), respectively (P=0.59). Conclusions: During a rapid-sequence induction with alfentanil and propofol, both rocuronium 0.6 mg kg[-1] and succinylcholine 1.0 mg kg[-1] provide clinically acceptable intubation conditions in 60 s in patients scheduled for emergency surgery. Under the conditions of this rapid-sequence induction regimen rocuronium may be a substitute for succinylcholine.
Original languageEnglish
JournalEuropean Journal of Anaesthesiology
Volume22
Issue number10
Pages (from-to)748-53
Number of pages6
ISSN0265-0215
Publication statusPublished - 1 Oct 2005

    Research areas

  • Abdomen, Adolescent, Adult, Aged, Aged, 80 and over, Alfentanil, Androstanols, Anesthesia, Intravenous, Anesthetics, Intravenous, Blood Pressure, Double-Blind Method, Emergency Medical Services, Female, Gynecologic Surgical Procedures, Heart Rate, Humans, Intubation, Intratracheal, Male, Middle Aged, Neuromuscular Depolarizing Agents, Neuromuscular Nondepolarizing Agents, Pneumonia, Aspiration, Propofol, Risk, Succinylcholine

ID: 32796520