Intrinsically photosensitive retinal ganglion cell function in relation to age: a pupillometric study in humans with special reference to the age-related optic properties of the lens

Kristina Herbst; Birgit Sander; Henrik Lund-Andersen; Adam Elias Broendsted; Line Kessel; Michael Stormly Hansen; Aki Kawasaki

doi:10.1186/1471-2415-12-4

Intrinsically photosensitive retinal ganglion cell function in relation to age: a pupillometric study in humans with special reference to the age-related optic properties of the lens

Kristina Herbst, Birgit Sander, Henrik Lund-Andersen, Adam Elias Broendsted, Line Kessel, Michael Stormly Hansen, Aki Kawasaki

Department of Ophthalmology

64 Citations (Scopus)

Abstract

The activity of melanopsin containing intrinsically photosensitive ganglion retinal cells (ipRGC) can be assessed by a means of pupil responses to bright blue (appr.480 nm) light. Due to age related factors in the eye, particularly, structural changes of the lens, less light reaches retina. The aim of this study was to examine how age and in vivo measured lens transmission of blue light might affect pupil light responses, in particular, mediated by the ipRGC.

Original language	English
Journal	B M C Ophthalmology
Volume	12
Pages (from-to)	4
ISSN	1471-2415
DOIs	https://doi.org/10.1186/1471-2415-12-4
Publication status	Published - 2012

Keywords

Adult
Age Factors
Aged
Aging
Area Under Curve
Female
Humans
Lens, Crystalline
Light
Male
Middle Aged
Photoreceptor Cells, Vertebrate
Pupil
Reflex, Pupillary
Retinal Ganglion Cells
Rod Opsins

Access to Document

10.1186/1471-2415-12-4

Cite this

Intrinsically photosensitive retinal ganglion cell function in relation to age: a pupillometric study in humans with special reference to the age-related optic properties of the lens. / Herbst, Kristina; Sander, Birgit; Lund-Andersen, Henrik et al.
In: B M C Ophthalmology, Vol. 12, 2012, p. 4.

Research output: Contribution to journal › Journal article › Research › peer-review

@article{7b9732068be14a7da00118197f3c6556,

title = "Intrinsically photosensitive retinal ganglion cell function in relation to age: a pupillometric study in humans with special reference to the age-related optic properties of the lens",

abstract = "The activity of melanopsin containing intrinsically photosensitive ganglion retinal cells (ipRGC) can be assessed by a means of pupil responses to bright blue (appr.480 nm) light. Due to age related factors in the eye, particularly, structural changes of the lens, less light reaches retina. The aim of this study was to examine how age and in vivo measured lens transmission of blue light might affect pupil light responses, in particular, mediated by the ipRGC.",

keywords = "Adult, Age Factors, Aged, Aging, Area Under Curve, Female, Humans, Lens, Crystalline, Light, Male, Middle Aged, Photoreceptor Cells, Vertebrate, Pupil, Reflex, Pupillary, Retinal Ganglion Cells, Rod Opsins",

author = "Kristina Herbst and Birgit Sander and Henrik Lund-Andersen and Broendsted, \{Adam Elias\} and Line Kessel and Hansen, \{Michael Stormly\} and Aki Kawasaki",

year = "2012",

doi = "10.1186/1471-2415-12-4",

language = "English",

volume = "12",

pages = "4",

journal = "B M C Ophthalmology",

issn = "1471-2415",

publisher = "BioMed Central Ltd",

}

TY - JOUR

T1 - Intrinsically photosensitive retinal ganglion cell function in relation to age

T2 - a pupillometric study in humans with special reference to the age-related optic properties of the lens

AU - Herbst, Kristina

AU - Sander, Birgit

AU - Lund-Andersen, Henrik

AU - Broendsted, Adam Elias

AU - Kessel, Line

AU - Hansen, Michael Stormly

AU - Kawasaki, Aki

PY - 2012

Y1 - 2012

N2 - The activity of melanopsin containing intrinsically photosensitive ganglion retinal cells (ipRGC) can be assessed by a means of pupil responses to bright blue (appr.480 nm) light. Due to age related factors in the eye, particularly, structural changes of the lens, less light reaches retina. The aim of this study was to examine how age and in vivo measured lens transmission of blue light might affect pupil light responses, in particular, mediated by the ipRGC.

AB - The activity of melanopsin containing intrinsically photosensitive ganglion retinal cells (ipRGC) can be assessed by a means of pupil responses to bright blue (appr.480 nm) light. Due to age related factors in the eye, particularly, structural changes of the lens, less light reaches retina. The aim of this study was to examine how age and in vivo measured lens transmission of blue light might affect pupil light responses, in particular, mediated by the ipRGC.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aging

KW - Area Under Curve

KW - Female

KW - Humans

KW - Lens, Crystalline

KW - Light

KW - Male

KW - Middle Aged

KW - Photoreceptor Cells, Vertebrate

KW - Pupil

KW - Reflex, Pupillary

KW - Retinal Ganglion Cells

KW - Rod Opsins

UR - https://www.scopus.com/pages/publications/84862208450

U2 - 10.1186/1471-2415-12-4

DO - 10.1186/1471-2415-12-4

M3 - Journal article

C2 - 22471313

SN - 1471-2415

VL - 12

SP - 4

JO - B M C Ophthalmology

JF - B M C Ophthalmology

ER -

Intrinsically photosensitive retinal ganglion cell function in relation to age: a pupillometric study in humans with special reference to the age-related optic properties of the lens

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this