Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study

Florian Kurth; Michel Develoux; Matthieu Mechain; Jan Clerinx; Spinello Antinori; Ida E Gjørup; Joaquím Gascon; Kristine Mørch; Emanuele Nicastri; Michael Ramharter; Alessandro Bartoloni; Leo Visser; Thierry Rolling; Philipp Zanger; Guido Calleri; Joaquín Salas-Coronas; Henrik Nielsen; Gudrun Just-Nübling; Andreas Neumayr; Anna Hachfeld; Matthias L Schmid; Pietro Antonini; Peter Pongratz; Peter Kern; José Saraiva da Cunha; Antoni Soriano-Arandes; Mirjam Schunk; Norbert Suttorp; Christoph Hatz; Thomas Zoller; TropNet Severe Malaria Investigator Group

doi:10.1093/cid/civ575

Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study

Florian Kurth, Michel Develoux, Matthieu Mechain, Jan Clerinx, Spinello Antinori, Ida E Gjørup, Joaquím Gascon, Kristine Mørch, Emanuele Nicastri, Michael Ramharter, Alessandro Bartoloni, Leo Visser, Thierry Rolling, Philipp Zanger, Guido Calleri, Joaquín Salas-Coronas, Henrik Nielsen, Gudrun Just-Nübling, Andreas Neumayr, Anna HachfeldMatthias L Schmid, Pietro Antonini, Peter Pongratz, Peter Kern, José Saraiva da Cunha, Antoni Soriano-Arandes, Mirjam Schunk, Norbert Suttorp, Christoph Hatz, Thomas Zoller, TropNet Severe Malaria Investigator Group

Department of Cardiology

46 Citations (Scopus)

Abstract

Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.

Original language	English
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	61
Issue number	9
Pages (from-to)	1441-4
Number of pages	4
ISSN	1058-4838
DOIs	https://doi.org/10.1093/cid/civ575
Publication status	Published - 1 Nov 2015

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10.1093/cid/civ575

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Kurth, F., Develoux, M., Mechain, M., Clerinx, J., Antinori, S., Gjørup, I. E., Gascon, J., Mørch, K., Nicastri, E., Ramharter, M., Bartoloni, A., Visser, L., Rolling, T., Zanger, P., Calleri, G., Salas-Coronas, J., Nielsen, H., Just-Nübling, G., Neumayr, A., ... TropNet Severe Malaria Investigator Group (2015). Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 61(9), 1441-4. https://doi.org/10.1093/cid/civ575

Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study. / Kurth, Florian; Develoux, Michel; Mechain, Matthieu et al.
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 61, No. 9, 01.11.2015, p. 1441-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Kurth, F, Develoux, M, Mechain, M, Clerinx, J, Antinori, S, Gjørup, IE, Gascon, J, Mørch, K, Nicastri, E, Ramharter, M, Bartoloni, A, Visser, L, Rolling, T, Zanger, P, Calleri, G, Salas-Coronas, J, Nielsen, H, Just-Nübling, G, Neumayr, A, Hachfeld, A, Schmid, ML, Antonini, P, Pongratz, P, Kern, P, Saraiva da Cunha, J, Soriano-Arandes, A, Schunk, M, Suttorp, N, Hatz, C, Zoller, T & TropNet Severe Malaria Investigator Group 2015, 'Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 61, no. 9, pp. 1441-4. https://doi.org/10.1093/cid/civ575

Kurth F, Develoux M, Mechain M, Clerinx J, Antinori S, Gjørup IE et al. Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2015 Nov 1;61(9):1441-4. doi: 10.1093/cid/civ575

Kurth, Florian ; Develoux, Michel ; Mechain, Matthieu et al. / Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe : The TropNet Severe Malaria Study. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2015 ; Vol. 61, No. 9. pp. 1441-4.

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title = "Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study",

abstract = "Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.",

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AU - Neumayr, Andreas

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AU - Schmid, Matthias L

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AB - Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.

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Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study

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