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Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

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Kristensen, David Møbjerg ; Hass, Ulla ; Lesné, Laurianne ; Poulsen, Grete Lottrup ; Jacobsen, Pernille Rosenskjold ; Desdoits-Lethimonier, Christele ; Boberg, Julie ; Petersen, Jørgen Holm ; Toppari, Jorma ; Jensen, Tina Kold ; Brunak, Søren ; Skakkebaek, Niels E ; Nellemann, Christine ; Main, Katharina M ; Jégou, Bernard ; Leffers, Henrik. / Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. In: Human Reproduction. 2011 ; Vol. 26, No. 1. pp. 235-44.

Bibtex

@article{66e30c4006304f179d82a27e0e5878d7,
title = "Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat",
abstract = "More than half of pregnant women in the Western world report intake of mild analgesics, and some of these drugs have been associated with anti-androgenic effects in animal experiments. Intrauterine exposure to anti-androgens is suspected to contribute to the recent increase in male reproductive problems, and many of the anti-androgenic compounds are like the mild analgesics potent inhibitors of prostaglandin synthesis. Therefore, it appears imperative to further investigate the potential endocrine disrupting properties of mild analgesics.",
author = "Kristensen, {David M{\o}bjerg} and Ulla Hass and Laurianne Lesn{\'e} and Poulsen, {Grete Lottrup} and Jacobsen, {Pernille Rosenskjold} and Christele Desdoits-Lethimonier and Julie Boberg and Petersen, {J{\o}rgen Holm} and Jorma Toppari and Jensen, {Tina Kold} and S{\o}ren Brunak and Skakkebaek, {Niels E} and Christine Nellemann and Main, {Katharina M} and Bernard J{\'e}gou and Henrik Leffers",
year = "2011",
month = "1",
day = "1",
doi = "10.1093/humrep/deq323",
language = "English",
volume = "26",
pages = "235--44",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

AU - Kristensen, David Møbjerg

AU - Hass, Ulla

AU - Lesné, Laurianne

AU - Poulsen, Grete Lottrup

AU - Jacobsen, Pernille Rosenskjold

AU - Desdoits-Lethimonier, Christele

AU - Boberg, Julie

AU - Petersen, Jørgen Holm

AU - Toppari, Jorma

AU - Jensen, Tina Kold

AU - Brunak, Søren

AU - Skakkebaek, Niels E

AU - Nellemann, Christine

AU - Main, Katharina M

AU - Jégou, Bernard

AU - Leffers, Henrik

PY - 2011/1/1

Y1 - 2011/1/1

N2 - More than half of pregnant women in the Western world report intake of mild analgesics, and some of these drugs have been associated with anti-androgenic effects in animal experiments. Intrauterine exposure to anti-androgens is suspected to contribute to the recent increase in male reproductive problems, and many of the anti-androgenic compounds are like the mild analgesics potent inhibitors of prostaglandin synthesis. Therefore, it appears imperative to further investigate the potential endocrine disrupting properties of mild analgesics.

AB - More than half of pregnant women in the Western world report intake of mild analgesics, and some of these drugs have been associated with anti-androgenic effects in animal experiments. Intrauterine exposure to anti-androgens is suspected to contribute to the recent increase in male reproductive problems, and many of the anti-androgenic compounds are like the mild analgesics potent inhibitors of prostaglandin synthesis. Therefore, it appears imperative to further investigate the potential endocrine disrupting properties of mild analgesics.

U2 - 10.1093/humrep/deq323

DO - 10.1093/humrep/deq323

M3 - Journal article

VL - 26

SP - 235

EP - 244

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 1

ER -

ID: 31058620