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Intratympanic Steroid for Menière's Disease: A Systematic Review

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Devantier, Louise ; Djurhuus, Bjarki Ditlev ; Hougaard, Dan Dupont ; Händel, Mina Nicole ; Guldfred, Frank Liviu-Adelin ; Schmidt, Jesper Hvass ; Edemann-Callesen, Henriette. / Intratympanic Steroid for Menière's Disease : A Systematic Review. In: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 2019 ; Vol. 40, No. 6. pp. 806-812.

Bibtex

@article{55dbf3d6c3764e11ba343223a7fa4b42,
title = "Intratympanic Steroid for Meni{\`e}re's Disease: A Systematic Review",
abstract = "OBJECTIVES: To investigate the beneficial effects and safety of intratympanic steroid installation compared with placebo in patients with Meni{\`e}re's disease.METHODS: We performed a systematic literature search in MEDLINE and EMBASE for existing systematic reviews and individual randomized controlled trials (RCTs). Studies were included if they investigated the usage intratympanic steroids in patients aged 18 and above, with definite or probable Meni{\`e}re's disease. The quality of the identified existing reviews was assessed using the AMSTAR tool. The risk of bias in RCTs was assessed using the Cochrane Risk of Bias Tool and overall quality of the individual outcomes was evaluated using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) method.RESULTS: The literature search provided four systematic reviews, from which one yielded a sufficient AMSTAR evaluation and subsequently provided three RCTs relevant for inclusion. Due to the lack of sufficient reporting of the data, quantitative synthesis was not applicable. In the qualitative synthesis for the primary outcome, the results from the RCTs showed that there was a slight indication of steroid treatment reducing the frequency of vertiginous attacks. No serious adverse events were reported. Based on the GRADE approach the quality for both findings is very low. No studies reported on the secondary outcomes.CONCLUSION: The effect of intratympanic steroid treatment in Meni{\`e}re's disease is questionable. There is a great need for further research to sufficiently assess whether steroid treatment may be considered as a safe and effective treatment for patients with Meni{\`e}re's disease.",
author = "Louise Devantier and Djurhuus, {Bjarki Ditlev} and Hougaard, {Dan Dupont} and H{\"a}ndel, {Mina Nicole} and Guldfred, {Frank Liviu-Adelin} and Schmidt, {Jesper Hvass} and Henriette Edemann-Callesen",
year = "2019",
month = "7",
doi = "10.1097/MAO.0000000000002255",
language = "English",
volume = "40",
pages = "806--812",
journal = "Otology and Neurotology",
issn = "1531-7129",
publisher = "Lippincott Williams & Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Intratympanic Steroid for Menière's Disease

T2 - A Systematic Review

AU - Devantier, Louise

AU - Djurhuus, Bjarki Ditlev

AU - Hougaard, Dan Dupont

AU - Händel, Mina Nicole

AU - Guldfred, Frank Liviu-Adelin

AU - Schmidt, Jesper Hvass

AU - Edemann-Callesen, Henriette

PY - 2019/7

Y1 - 2019/7

N2 - OBJECTIVES: To investigate the beneficial effects and safety of intratympanic steroid installation compared with placebo in patients with Menière's disease.METHODS: We performed a systematic literature search in MEDLINE and EMBASE for existing systematic reviews and individual randomized controlled trials (RCTs). Studies were included if they investigated the usage intratympanic steroids in patients aged 18 and above, with definite or probable Menière's disease. The quality of the identified existing reviews was assessed using the AMSTAR tool. The risk of bias in RCTs was assessed using the Cochrane Risk of Bias Tool and overall quality of the individual outcomes was evaluated using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) method.RESULTS: The literature search provided four systematic reviews, from which one yielded a sufficient AMSTAR evaluation and subsequently provided three RCTs relevant for inclusion. Due to the lack of sufficient reporting of the data, quantitative synthesis was not applicable. In the qualitative synthesis for the primary outcome, the results from the RCTs showed that there was a slight indication of steroid treatment reducing the frequency of vertiginous attacks. No serious adverse events were reported. Based on the GRADE approach the quality for both findings is very low. No studies reported on the secondary outcomes.CONCLUSION: The effect of intratympanic steroid treatment in Menière's disease is questionable. There is a great need for further research to sufficiently assess whether steroid treatment may be considered as a safe and effective treatment for patients with Menière's disease.

AB - OBJECTIVES: To investigate the beneficial effects and safety of intratympanic steroid installation compared with placebo in patients with Menière's disease.METHODS: We performed a systematic literature search in MEDLINE and EMBASE for existing systematic reviews and individual randomized controlled trials (RCTs). Studies were included if they investigated the usage intratympanic steroids in patients aged 18 and above, with definite or probable Menière's disease. The quality of the identified existing reviews was assessed using the AMSTAR tool. The risk of bias in RCTs was assessed using the Cochrane Risk of Bias Tool and overall quality of the individual outcomes was evaluated using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) method.RESULTS: The literature search provided four systematic reviews, from which one yielded a sufficient AMSTAR evaluation and subsequently provided three RCTs relevant for inclusion. Due to the lack of sufficient reporting of the data, quantitative synthesis was not applicable. In the qualitative synthesis for the primary outcome, the results from the RCTs showed that there was a slight indication of steroid treatment reducing the frequency of vertiginous attacks. No serious adverse events were reported. Based on the GRADE approach the quality for both findings is very low. No studies reported on the secondary outcomes.CONCLUSION: The effect of intratympanic steroid treatment in Menière's disease is questionable. There is a great need for further research to sufficiently assess whether steroid treatment may be considered as a safe and effective treatment for patients with Menière's disease.

U2 - 10.1097/MAO.0000000000002255

DO - 10.1097/MAO.0000000000002255

M3 - Journal article

VL - 40

SP - 806

EP - 812

JO - Otology and Neurotology

JF - Otology and Neurotology

SN - 1531-7129

IS - 6

ER -

ID: 58098871