Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up

A Bertelsen; J Thorup; P V Pedersen; K Mauritzen; N E Skakkebaek

doi:10.1007/BF00452869

Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up

A Bertelsen, J Thorup, P V Pedersen, K Mauritzen, N E Skakkebaek

Department of Pediatrics

11 Citations (Scopus)

Abstract

The effect of intranasal LH-RH on cryptorchidism was investigated in 45 prepubertal boys with 68 undescended testes. A daily dose of 1.2 mg LH-RH was given for 4 weeks. A total of 16 testes (24%) descended. Follow-up examination 5 years later showed that relapse had occurred in two cases. Fifty-two testes did not descend during the LH-RH treatment. However, seven of these testes descended spontaneously during puberty. So far surgical treatment has been carried out in 39 of the remaining 45 testes. Anatomical anomalies (ectopic position of the testis, open processus vaginalis, abnormal epididymis) explained the failure of LH-RH to cause descent in the majority of the surgically treated cases.

Original language	English
Journal	European Journal of Pediatrics
Volume	146 Suppl 2
Pages (from-to)	S40-1
ISSN	0340-6199
DOIs	https://doi.org/10.1007/BF00452869
Publication status	Published - 1987

Keywords

Administration, Intranasal
Child
Clinical Trials as Topic
Cryptorchidism/drug therapy
Follow-Up Studies
Gonadotropin-Releasing Hormone/administration & dosage
Humans
Male
Time Factors

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10.1007/BF00452869

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title = "Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up",

abstract = "The effect of intranasal LH-RH on cryptorchidism was investigated in 45 prepubertal boys with 68 undescended testes. A daily dose of 1.2 mg LH-RH was given for 4 weeks. A total of 16 testes (24\%) descended. Follow-up examination 5 years later showed that relapse had occurred in two cases. Fifty-two testes did not descend during the LH-RH treatment. However, seven of these testes descended spontaneously during puberty. So far surgical treatment has been carried out in 39 of the remaining 45 testes. Anatomical anomalies (ectopic position of the testis, open processus vaginalis, abnormal epididymis) explained the failure of LH-RH to cause descent in the majority of the surgically treated cases.",

keywords = "Administration, Intranasal, Child, Clinical Trials as Topic, Cryptorchidism/drug therapy, Follow-Up Studies, Gonadotropin-Releasing Hormone/administration \& dosage, Humans, Male, Time Factors",

author = "A Bertelsen and J Thorup and Pedersen, \{P V\} and K Mauritzen and Skakkebaek, \{N E\}",

year = "1987",

doi = "10.1007/BF00452869",

language = "English",

volume = "146 Suppl 2",

pages = "S40--1",

journal = "European Journal of Pediatrics",

issn = "0340-6199",

publisher = "Springer Science and Business Media Deutschland GmbH",

}

TY - JOUR

T1 - Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up

AU - Bertelsen, A

AU - Thorup, J

AU - Pedersen, P V

AU - Mauritzen, K

AU - Skakkebaek, N E

PY - 1987

Y1 - 1987

N2 - The effect of intranasal LH-RH on cryptorchidism was investigated in 45 prepubertal boys with 68 undescended testes. A daily dose of 1.2 mg LH-RH was given for 4 weeks. A total of 16 testes (24%) descended. Follow-up examination 5 years later showed that relapse had occurred in two cases. Fifty-two testes did not descend during the LH-RH treatment. However, seven of these testes descended spontaneously during puberty. So far surgical treatment has been carried out in 39 of the remaining 45 testes. Anatomical anomalies (ectopic position of the testis, open processus vaginalis, abnormal epididymis) explained the failure of LH-RH to cause descent in the majority of the surgically treated cases.

AB - The effect of intranasal LH-RH on cryptorchidism was investigated in 45 prepubertal boys with 68 undescended testes. A daily dose of 1.2 mg LH-RH was given for 4 weeks. A total of 16 testes (24%) descended. Follow-up examination 5 years later showed that relapse had occurred in two cases. Fifty-two testes did not descend during the LH-RH treatment. However, seven of these testes descended spontaneously during puberty. So far surgical treatment has been carried out in 39 of the remaining 45 testes. Anatomical anomalies (ectopic position of the testis, open processus vaginalis, abnormal epididymis) explained the failure of LH-RH to cause descent in the majority of the surgically treated cases.

KW - Administration, Intranasal

KW - Child

KW - Clinical Trials as Topic

KW - Cryptorchidism/drug therapy

KW - Follow-Up Studies

KW - Gonadotropin-Releasing Hormone/administration & dosage

KW - Humans

KW - Male

KW - Time Factors

UR - https://www.scopus.com/pages/publications/0023640549

U2 - 10.1007/BF00452869

DO - 10.1007/BF00452869

M3 - Journal article

C2 - 2891520

SN - 0340-6199

VL - 146 Suppl 2

SP - S40-1

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

ER -

Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up

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Keywords

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