Intracranial Mesenchymal Tumor, FET-CREB Fusion Positive, Evaluated With 18F-FET and 18F-FDG PET/CT

Intracranial mesenchymal tumor, FET-CREB fusion positive, is a newly recognized and rare CNS tumor that occurs primarily in children and young adults. It is regarded as the intracranial variant of angiomatoid fibrous histiocytoma. Extracranial angiomatoid fibrous histiocytomas are typically located in the extremities and usually discernible on a 18F-FDG PET/CT scanning. We present a 50-year-old man with recurrence of a primary intracranial mesenchymal tumor with equivocal 18F-FDG PET/CT findings but with subsequent highly increased metabolic activity using 18F-FET PET/CT confirming tumor recurrence. This case highlights the importance of 18F-FET PET/CT, as opposed to 18F-FDG, in the clinical evaluation of this rare intracranial mesenchymal tumor.